- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Related Products
|
VEGF Antibody recognizes vascular endothelial growth factor A (VEGFA), a secreted signaling protein that serves as one of the most important regulators of angiogenesis, vascular development, and endothelial cell function. VEGF promotes blood vessel formation by binding VEGF receptors, primarily VEGFR1 and VEGFR2, on endothelial cells to stimulate proliferation, migration, survival, and vascular permeability. Through these signaling pathways, VEGF controls physiological processes such as embryonic vascular development, tissue repair, and wound healing, while abnormal VEGF activity contributes to disease-associated neovascularization. VEGF Antibody is widely used to investigate angiogenesis, endothelial signaling, tumor vascularization, and hypoxia-driven cellular responses.
VEGF expression is strongly regulated by oxygen availability, with hypoxic conditions activating HIF-mediated transcriptional pathways that increase VEGF production. In cancer biology, tumor cells frequently upregulate VEGF to promote the formation of new blood vessels that supply oxygen and nutrients required for continued tumor growth. Elevated VEGF expression has been reported in many solid tumors and is associated with angiogenesis, tumor progression, metastasis, and changes within the tumor microenvironment. As an Angiogenesis Growth Factor Antibody, VEGF Antibody is an important tool for studying vascular remodeling and cancer-associated angiogenic signaling.
Beyond oncology, VEGF plays important roles in cardiovascular biology, inflammation, retinal vascular disorders, and tissue regeneration. VEGF signaling regulates endothelial barrier function, vascular permeability, and interactions between endothelial cells and surrounding tissues. Multiple VEGF isoforms generated through alternative splicing contribute to differences in localization, receptor binding, and biological activity. Research into VEGF pathways has provided major insight into vascular biology and has supported the development of therapeutic strategies targeting abnormal angiogenesis.
VEGF Antibody, an Angiogenesis Growth Factor Antibody, enables researchers to study VEGFA expression across models of vascular development, cancer progression, inflammation, and tissue remodeling. NSJ Bioreagents offers VEGF antibodies validated across multiple applications, including Western blot, immunohistochemistry, and flow cytometry, supporting investigation of VEGF-mediated signaling pathways, endothelial cell regulation, and mechanisms controlling blood vessel formation.
Explore additional Angiogenesis Antibodies for targets involved in endothelial cell signaling, vascular development, tumor angiogenesis, and blood vessel formation.
The stated application concentrations are suggested starting points. Titration of the VEGF Antibody / Angiogenesis Growth Factor Antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Human recombinant protein, A isoform (AA 27-191) was used as the immunogen for this VEGF antibody.
After reconstitution, the VEGF antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
VEGFA Antibody, Vascular Endothelial Growth Factor Antibody, Vascular Permeability Factor Antibody, VPF Antibody, VEGF-A Antibody, Endothelial Growth Factor Antibody
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.