- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Related Products
|
HSPC150 Antibody recognizes UBE2T, also known as HSPC150, an E2 ubiquitin-conjugating enzyme that participates in the transfer of ubiquitin to target proteins. UBE2T functions as an intermediary between ubiquitin-activating E1 enzymes and specific E3 ubiquitin ligases, helping regulate protein activity, localization, stability, and interactions. HSPC150 is particularly important in pathways that maintain genomic integrity and coordinate cellular responses to DNA damage. A UBE2T Antibody can therefore be used to investigate ubiquitin-dependent protein regulation and mechanisms involved in DNA repair.
UBE2T is a central component of the Fanconi anemia DNA repair pathway, which protects cells against DNA interstrand crosslinks and replication-associated damage. In this pathway, UBE2T cooperates with the Fanconi anemia core complex to promote monoubiquitination of FANCD2 and FANCI. This modification facilitates recruitment and activity of downstream DNA repair factors at sites of genomic damage. Disruption of UBE2T activity can impair this process and compromise genome stability, linking HSPC150 function to DNA damage signaling, chromosome maintenance, and Fanconi anemia biology.
Altered UBE2T expression has also attracted considerable attention in cancer research. Elevated expression has been reported in multiple tumor types and has been associated with increased cell proliferation, survival, invasion, and tumor progression. Depending on cellular context, UBE2T can influence the abundance or activity of proteins involved in cell cycle regulation, DNA repair, and oncogenic signaling. An HSPC150 Antibody is consequently useful for examining UBE2T expression in experimental models of tumor biology and for investigating the relationship between ubiquitination, genomic instability, and malignant cell behavior.
An HSPC150 Antibody provides a research tool for studying UBE2T expression, E2 ubiquitin-conjugating enzyme activity, Fanconi anemia pathway signaling, DNA damage responses, protein regulation, and cancer biology.
For additional information on UBE2T and its role in ubiquitination and DNA damage repair, see our UBE2T Antibody / Ubiquitin-conjugating Enzyme E2 T page.
Optimal dilution of the HSPC150 Antibody / UBE2T Antibody should be determined by the researcher.
Amino acids QLVGIEKKFHPDV were used as the immunogen for this UBE2T / HSPC150 antibody.
Aliquot and store the UBE2T / HSPC150 antibody at -20oC.
HSPC150 antibody, UBE2T antibody, Ubiquitin-conjugating enzyme E2 T antibody, Ubiquitin carrier protein T antibody, E2 ubiquitin-conjugating enzyme T antibody
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.