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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
TL1A Antibody Mouse Monoclonal / TNFSF15 / VEGI [clone VEGI/1283] (V3348)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V3348-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
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V3348-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V3348SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | VEGI/1283 |
| Purity | Protein G affinity chromatography |
| Buffer | 1X PBS, pH 7.4 |
| UniProt | O95150 |
| Gene ID | 9966 |
| Localization | Cytoplasmic, cell surface, secreted |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This TL1A antibody is available for research use only. |
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TL1A antibody recognizes Tumor necrosis factor ligand superfamily member 15, also known as VEGI and encoded by the TNFSF15 gene. TL1A is a type II transmembrane cytokine belonging to the tumor necrosis factor ligand superfamily and is expressed primarily by endothelial cells, dendritic cells, and activated immune cell populations. TL1A Antibody Mouse Monoclonal is developed to detect endogenous VEGI in research applications focused on inflammatory signaling and angiogenic regulation.
TL1A functions as a ligand for death receptor 3, also known as TNFRSF25, initiating signaling pathways that regulate T cell activation, cytokine production, and apoptosis-related mechanisms. Through its interaction with TNFRSF25, TNFSF15 plays a central role in modulating adaptive immune responses, particularly in T helper cell differentiation and effector function. In addition to immune regulation, VEGI exerts anti-angiogenic effects by inhibiting endothelial cell proliferation and influencing vascular remodeling.
The TNFSF15 gene is located on chromosome 9q32 and produces a membrane-bound protein that can be cleaved to generate a soluble cytokine form. TL1A expression has been documented in vascular endothelium and inflamed tissues, and dysregulated TNFSF15 signaling has been associated with inflammatory bowel disease, autoimmune conditions, and tumor-associated vascular changes. In oncologic research, VEGI has been investigated for its ability to suppress tumor angiogenesis by limiting vascular support within the tumor microenvironment.
Because TL1A bridges vascular biology and immune activation, it remains an important target in studies examining endothelial-immune interactions and cytokine-driven inflammation. Altered expression of TNFSF15 may influence chronic inflammatory states and immune-mediated tissue injury across multiple organ systems.
Clone VEGI/1283 is a mouse monoclonal antibody that recognizes TL1A and supports studies of TNFSF15-mediated signaling, immune regulation, and VEGI-associated angiogenic pathways.
Titration of the TL1A antibody may be required for optimal performance.
A full length human recombinant protein was used as the immunogen for this TL1A antibody.
Store the TL1A antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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