- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Thyroid transcription factor 1 Antibody / TTF-1 / NX2.1 [clone NX2.1/9036] (V5552)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V5552-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
|
V5552-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
|
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V5552SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2b, kappa |
| Clone Name | NX2.1/9036 |
| Purity | Protein A/G affinity |
| UniProt | P43699 |
| Localization | Nucleus |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This Thyroid transcription factor 1 antibody is available for research use only. |
|
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Thyroid transcription factor 1 (NKX2-1) is a nuclear homeobox transcription factor that regulates epithelial lineage development in the lung, thyroid gland, and forebrain. The protein functions as a DNA-binding transcriptional regulator that controls expression of genes required for epithelial differentiation and organ development. The Thyroid transcription factor 1 Antibody recognizes this lineage-associated transcription factor, which localizes to the nuclei of epithelial cells in respiratory epithelium and thyroid follicular epithelium.
Thyroid transcription factor 1 antibody, also referred to as NKX2-1 antibody or TTF-1 antibody in the literature, detects a nuclear transcription factor that plays a central role in regulating tissue-specific gene expression. NKX2-1 contains a conserved homeobox DNA-binding domain that allows the protein to interact with regulatory regions of target genes and control transcriptional programs involved in epithelial lineage specification and differentiation.
In lung tissue, NKX2-1 regulates genes associated with respiratory epithelial identity and pulmonary epithelial differentiation. The transcription factor controls expression of several lung-specific genes including surfactant proteins that are produced by alveolar epithelial cells. Through these regulatory activities, NKX2-1 contributes to pulmonary epithelial development and maintenance of respiratory epithelial function.
In the thyroid gland, NKX2-1 functions as an important regulator of thyroid follicular epithelial cell differentiation and thyroid hormone biosynthesis. The transcription factor activates thyroid-specific genes including thyroglobulin and thyroid peroxidase that are essential for thyroid hormone production. These transcriptional regulatory functions establish NKX2-1 as a key factor in maintaining the differentiated phenotype of thyroid follicular epithelial cells.
Because NKX2-1 functions as a nuclear transcription factor controlling epithelial gene expression, it remains widely studied in research focused on epithelial lineage determination, developmental biology, and transcriptional regulation. A Thyroid transcription factor 1 antibody such as clone NX2.1/9036 provides a useful tool for studies investigating transcription factor localization, epithelial differentiation, and gene regulatory pathways associated with lung and thyroid epithelial tissues.
Optimal dilution of the Thyroid transcription factor 1 antibody should be determined by the researcher.
A recombinant fragment (within amino acids 1-200) of human TTF-1 protein was used as the immunogen for the Thyroid transcription factor 1 antibody.
Aliquot the Thyroid transcription factor 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
NKX2-1 antibody, TTF-1 antibody, TTF1 antibody, TITF1 antibody, Thyroid transcription factor antibody
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