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Home >> Antibodies >> TFEB Antibody

TFEB Antibody (F46977)

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  Catalog No Formulation Size Price (USD)  
Image F46977-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 399
Image
F46977-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 185
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TFEB antibody western blot analysis in HepG2 lysate. Expected molecular weight: 53-60 kDa (unmodified), 65-70 kDa (modified).
TFEB antibody western blot analysis in HepG2 lysate. Expected molecular weight: 53-60 kDa (unmodified), 65-70 kDa (modified).
Availability 1-3 business days
Species Reactivity Human
Predicted Reactivity Mouse
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt P19484
Applications Western blot : 1:1000
Limitations This TFEB antibody is available for research use only.
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Description

Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta.

Application Notes

Titration of the TFEB antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 271-300 from the human protein was used as the immunogen for this TFEB antibody.

Storage

Aliquot the TFEB antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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