- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
TAGAP Antibody / T cell activation Rho GTPase activating protein [clone 30T40] (FY13222)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY13222 | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA | 100 ul | 439 |
TAGAP antibody detects T cell activation Rho GTPase activating protein, encoded by the TAGAP gene. T cell activation Rho GTPase activating protein is a cytoplasmic regulator of the Rho family of small GTPases, controlling actin cytoskeleton remodeling and T cell receptor signaling. TAGAP antibody provides researchers with a reliable reagent to study immune cell activation, autoimmunity, and cytoskeletal regulation.
T cell activation Rho GTPase activating protein functions as a negative regulator of Rho GTPases by stimulating their intrinsic GTPase activity, converting active GTP bound forms into inactive GDP bound forms. Research using TAGAP antibody has shown that this regulation influences T cell activation thresholds and cytoskeletal reorganization during immune responses. By fine tuning Rho signaling, TAGAP modulates T cell migration, adhesion, and synapse formation, processes that are critical for adaptive immunity.
Genome wide association studies have identified TAGAP as a susceptibility locus for several autoimmune diseases, including multiple sclerosis, type 1 diabetes, rheumatoid arthritis, and celiac disease. Studies with TAGAP antibody have revealed that altered expression or polymorphisms in TAGAP influence T cell function, predisposing individuals to dysregulated immune responses. These findings highlight TAGAP as a genetic link between cytoskeletal regulation and autoimmunity.
Beyond its role in T cells, TAGAP is expressed in other immune lineages such as dendritic cells and macrophages. Research using TAGAP antibody has demonstrated roles in innate immune signaling, where TAGAP contributes to pattern recognition receptor pathways and cytokine production. This expands its relevance beyond adaptive immunity to innate immune regulation.
TAGAP antibody is widely used in western blotting, immunohistochemistry, and flow cytometry. Western blotting demonstrates inducible expression after immune stimulation, immunohistochemistry shows localization in lymphoid tissues, and flow cytometry quantifies expression across immune subsets. These applications make TAGAP antibody a versatile tool in immunology research.
By supplying validated TAGAP antibody reagents, NSJ Bioreagents supports studies into T cell activation, autoimmunity, and cytoskeletal regulation. Detection of T cell activation Rho GTPase activating protein provides a critical marker for understanding how immune cell signaling and cytoskeletal dynamics intersect.
Optimal dilution of the TAGAP antibody should be determined by the researcher.
A synthesized peptide derived from human TAGAP was used as the immunogen for the TAGAP antibody.
Store the TAGAP antibody at -20oC.
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.
Powered by Bioz