- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
SV2A Antibody Goat Polyclonal / Synaptic vesicle glycoprotein 2A (R36311)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
R36311-100UG | 0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide | 100 ug | 475 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse, Rat |
| Predicted Reactivity | Cow, Dog, Pig |
| Format | Antigen affinity purified |
| Host | Goat |
| Clonality | Polyclonal (goat origin) |
| Isotype | Goat Ig |
| Purity | Antigen affinity |
| Gene ID | 9900 |
| Applications | Western Blot : 0.3-1ug/ml ELISA (peptide) LOD : 1:64000 |
| Limitations | This SV2A antibody is available for research use only. |
|
Review this product on BioCompare and get a $20 Amazon gift card
|
Related Products
|
SV2A antibody recognizes Synaptic vesicle glycoprotein 2A, a transmembrane vesicular protein encoded by the SV2A gene that localizes predominantly to synaptic vesicles within presynaptic terminals. SV2A is broadly expressed throughout the central nervous system in both excitatory and inhibitory neurons, where it contributes to regulated neurotransmitter release and synaptic vesicle cycling. SV2A Antibody Goat Polyclonal is developed to detect endogenous Synaptic vesicle glycoprotein 2A in research applications focused on synaptic transmission and neuronal integrity.
Synaptic vesicle glycoprotein 2A is a member of the SV2 protein family, which includes SV2A, SV2B, and SV2C. The protein contains multiple transmembrane domains and resides within the membrane of synaptic vesicles, where it is thought to regulate vesicle priming, exocytosis efficiency, and calcium-dependent neurotransmitter release. Although the precise molecular mechanism remains under investigation, SV2A is recognized as an essential modulator of synaptic function and vesicle trafficking.
The SV2A gene is located on chromosome 1q21.3 and is highly enriched in synapse-dense regions of the brain, including cortex, hippocampus, and cerebellum. In addition to neuronal tissues, SV2A is expressed at lower levels in certain endocrine and neuroendocrine cells, consistent with its role in regulated secretory pathways. Alterations in SV2A expression or function have been associated with epilepsy and other neurologic disorders, and Synaptic vesicle glycoprotein 2A serves as the molecular binding target of the antiepileptic drug levetiracetam, underscoring its translational relevance.
Because SV2A is consistently present in presynaptic terminals, it is widely used as a marker of synaptic density and neuronal connectivity in studies of neurodevelopment, neurodegeneration, and brain injury. Changes in SV2A levels may reflect synaptic remodeling or loss in disease models and experimental systems.
By targeting SV2A, this goat polyclonal antibody supports studies of synaptic vesicle biology, neurotransmitter release mechanisms, and neuronal network organization across diverse research settings.
Optimal dilution of the SV2A antibody should be determined by the researcher.
Amino acids TVELYPSDKRTTA were used as the immunogen for this SV2A antibody.
Aliquot and store the SV2A antibody at -20oC.
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.
Powered by Bioz
