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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
STAM2 Antibody / Hbp Antibody (R35458)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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R35458-100UG | 0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide | 100 ug | 475 |
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| Availability | 1-3 business days |
| Species Reactivity | Human |
| Predicted Reactivity | Dog, Mouse |
| Format | Antigen affinity purified |
| Host | Goat |
| Clonality | Polyclonal (goat origin) |
| Isotype | Goat Ig |
| Purity | Antigen affinity |
| Gene ID | 10254 |
| Applications | Western Blot : 1-3ug/ml ELISA (peptide) LOD : 1:8000 |
| Limitations | This STAM2 Antibody / Hbp Antibody is available for research use only. |
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STAM2 Antibody / Hbp Antibody recognizes Signal Transducing Adaptor Molecule 2, a cytoplasmic adaptor protein historically known as Hbp (Hrs-binding protein) because of its direct interaction with Hrs (HGS). Hbp is a core component of the ESCRT-0 complex, where it cooperates with Hrs to recognize ubiquitinated membrane proteins and direct them into the endosomal sorting pathway. Through this activity, Hbp helps determine whether activated cell-surface receptors are recycled back to the plasma membrane or targeted for lysosomal degradation, making it an important regulator of receptor signaling and intracellular protein turnover.
Hbp contains an SH3 domain and multiple protein interaction motifs that allow it to function as a scaffold for signaling and membrane trafficking proteins. Together with Hrs, Hbp recruits ubiquitinated cargo and additional ESCRT machinery required for multivesicular body formation. This process is essential for the downregulation of receptor tyrosine kinases, cytokine receptors, and other signaling molecules following activation. By controlling receptor trafficking, Hbp influences signaling pathways involved in cell growth, differentiation, immune responses, and survival. Dysregulation of Hbp-mediated endosomal sorting has been linked to abnormal receptor signaling, impaired protein homeostasis, and cancer progression.
Because Hbp functions at the intersection of signal transduction and vesicle trafficking, it is widely studied in cell biology, oncology, neuroscience, and immunology. The protein localizes predominantly to early endosomes, where it displays a characteristic punctate cytoplasmic distribution that frequently concentrates in the perinuclear region. Studies of Hbp often focus on receptor internalization, endosomal maturation, ubiquitin-dependent cargo recognition, ESCRT complex assembly, and lysosomal targeting. Hbp also participates in the cellular response to growth factors and cytokines by regulating the duration and intensity of downstream signaling events.
An STAM2 Antibody is a valuable tool for investigating Hbp expression, intracellular localization, and endosomal trafficking mechanisms in cultured cells and tissue specimens. Researchers frequently use Hbp Antibody reagents to examine ESCRT-0 function, receptor downregulation, ubiquitin-mediated protein sorting, and vesicle transport in both normal physiology and disease models.
Explore our STAM2 Antibody / Signal Transducing Adaptor Molecule 2 Antibody page to learn more about STAM2 biology, endosomal sorting, and receptor trafficking.
Optimal dilution of the STAM2 Antibody / Hbp Antibody should be determined by the researcher.
Amino acids QSIDPTDSKPDSQD were used as the immunogen for this STAM2 antibody. No cross-reaction expected with STAM1.
Aliquot and store the STAM2 antibody at -20oC.
STAM2 Antibody, Signal Transducing Adaptor Molecule 2 Antibody, STAM-2 Antibody, Hbp Antibody, Hrs-Binding Protein Antibody
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