- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
SOX10 Goat Polyclonal Antibody (R33380)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
R33380-100UG | 0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide | 100 ug | 475 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Predicted Reactivity | Mouse, Rat, Dog, Pig, Cow |
| Format | Antigen affinity purified |
| Host | Goat |
| Clonality | Polyclonal (goat origin) |
| Isotype | Goat Ig |
| Purity | Antigen affinity |
| Gene ID | 6663 |
| Applications | Western Blot : 0.1-0.3ug/ml ELISA (peptide) LOD : 1:128000 |
| Limitations | This SOX10 Goat Polyclonal Antibody is available for research use only. |
|
Review this product on BioCompare and get a $20 Amazon gift card
|
Related Products
|
SOX10 Goat Polyclonal Antibody recognizes SOX10, a nuclear transcription factor belonging to the SRY-related high-mobility-group box family of DNA-binding proteins. Also known as SRY-Box Transcription Factor 10, SOX10 regulates gene expression programs involved in neural crest development, cellular differentiation, and nervous system formation. The protein contains a conserved high-mobility-group (HMG) domain that mediates DNA binding and contributes to transcriptional regulation. SOX10 is particularly important in melanocytes, Schwann cells, oligodendrocytes, and developing peripheral nervous system structures.
During embryonic development, SOX10 helps coordinate the survival, migration, and differentiation of neural crest-derived progenitor cells. It interacts with other transcriptional regulators to establish specialized cellular lineages, including melanocytes and peripheral glial cells. In melanocyte development, SOX10 promotes expression of microphthalmia-associated transcription factor (MITF), a central regulator of pigmentation and melanocyte differentiation. Disruption of this pathway can interfere with normal melanocyte development and contribute to pigmentation abnormalities.
SOX10 also plays essential roles in nervous system development and myelination. In Schwann cells, it regulates transcriptional programs required for peripheral nerve maturation and myelin formation. Within the central nervous system, SOX10 contributes to oligodendrocyte differentiation and the expression of myelin-associated proteins. These activities make SRY-Box Transcription Factor 10 an important marker for investigating glial development, neural crest biology, and nervous system organization.
In cancer research, SOX10 is widely studied as a marker of melanocytic differentiation. Many melanomas retain nuclear SOX10 expression, making the protein useful for investigating melanocytic tumors and their biological characteristics. SOX10 expression is also observed in certain peripheral nerve sheath tumors and subsets of breast and salivary gland carcinomas. Its expression is therefore not exclusive to melanoma, and interpretation requires consideration of additional markers and tissue characteristics.
Pathogenic variants in SOX10 are associated with neurocristopathies, including Waardenburg syndrome and Waardenburg-Shah syndrome. These conditions can involve pigmentation abnormalities, hearing impairment, and intestinal aganglionosis, reflecting the protein's importance in neural crest-derived tissues. SOX10 is also investigated in melanoma progression, cellular plasticity, and changes in differentiation state.
A SOX10 Goat Polyclonal Antibody from NSJ Bioreagents supports research investigating SOX10 expression, neural crest differentiation, glial development, melanocytic lineage identity, and molecular mechanisms associated with SOX10-related disorders.
For a recombinant monoclonal alternative targeting the same transcription factor, see our SOX10 Antibody rSOX10/1074 (V3563), featuring WB, IHC, and protein microarray validation.
Optimal dilution of the SOX10 Goat Polyclonal Antibody should be determined by the researcher.
Amino acids DAKAQVKTETAGPQ were used as the immunogen for this SOX10 Goat Polyclonal Antibody.
Aliquot and store the SOX10 Goat Polyclonal Antibody at -20oC.
SRY-Box Transcription Factor 10 antibody, SRY-Box 10 antibody, SRY-Related HMG-Box 10 antibody, SOX-10 antibody, SOX 10 antibody, Transcription Factor SOX10 antibody, SRY-Box Protein 10 antibody
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.
Powered by Bioz
