- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
SORLA Antibody / Endosomal Sorting Receptor Antibody (R36176)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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R36176-100UG | 0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide | 100 ug | 475 |
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| Availability | 1-3 business days |
| Species Reactivity | Mouse |
| Predicted Reactivity | Human, Rat, Dog, Cow |
| Format | Antigen affinity purified |
| Host | Goat |
| Clonality | Polyclonal (goat origin) |
| Isotype | Goat Ig |
| Purity | Antigen affinity |
| Gene ID | 6653 |
| Applications | Western Blot : 0.3-1ug/ml ELISA (peptide) LOD : 1:32000 |
| Limitations | This SORLA Antibody / Endosomal Sorting Receptor Antibody is available for research use only. |
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SORLA Antibody / Endosomal Sorting Receptor Antibody recognizes SORLA (SORL1), a member of the VPS10-domain receptor family that regulates intracellular protein trafficking through the endosomal-lysosomal network. SORLA functions as a multifunctional sorting receptor that directs cargo proteins between the Golgi apparatus, endosomes, lysosomes, and plasma membrane, thereby maintaining protein homeostasis and receptor recycling. Through these trafficking activities, SORLA controls the intracellular distribution and degradation of numerous proteins, making it an essential regulator of endosomal sorting and vesicular transport. This antibody is well suited for studies of intracellular trafficking, membrane protein recycling, and endosomal biology.
SORLA is highly expressed in neurons, where it regulates trafficking of amyloid precursor protein (APP) and limits its processing into amyloid-beta peptides. Consequently, reduced SORLA expression has been strongly associated with Alzheimer's disease and other neurodegenerative disorders. Beyond the nervous system, SORLA also regulates lipoprotein metabolism, growth factor receptor trafficking, insulin signaling, and cellular responses to metabolic stress. Its ability to coordinate endosomal cargo sorting places SORLA at the center of multiple pathways controlling cellular homeostasis and receptor availability.
Altered SORLA expression has also been reported in breast, ovarian, prostate, and other cancers, where dysregulated intracellular trafficking can influence tumor growth, migration, and therapeutic response. Ongoing research continues to expand the understanding of SORLA in neurobiology, metabolism, and cancer, identifying the receptor as both a valuable biomarker and a potential therapeutic target. SORLA Antibody / Endosomal Sorting Receptor Antibody is an excellent tool for investigations of endosomal sorting, receptor recycling, vesicular transport, Alzheimer's disease, intracellular protein trafficking, and cancer biology.
Explore our SORL1 Antibody / Sortilin-Related Receptor 1 page to learn more about this key regulator of intracellular protein trafficking, endosomal sorting, and receptor recycling.
Optimal dilution of the SORLA Antibody / Endosomal Sorting Receptor Antibody should be determined by the researcher.
Amino acids TGFSDDVPMVIA were used as the immunogen for this SORLA antibody.
Aliquot and store the SORLA antibody at -20oC.
SORLA antibody, SORL1 antibody, Sortilin-Related Receptor 1 antibody, LR11 antibody, VPS10 Domain Receptor antibody, Sorting Protein-Related Receptor antibody
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