- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
SMARCB1 Antibody rSMARCB1/4588 / Integrase interactor 1 Monoclonal Antibody [clone rSMARCB1/4588] (V9581)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V9581-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
|
V9581-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
|
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V9581SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG1, kappa |
| Clone Name | rSMARCB1/4588 |
| Purity | Protein A/G affinity |
| UniProt | Q12824 |
| Localization | Nucleus |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This SMARCB1 Antibody rSMARCB1/4588 / Integrase interactor 1 Monoclonal Antibody is available for research use only. |
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SMARCB1 Antibody detects SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 protein. The SMARCB1 gene, which encodes a functionally uncharacterized protein component of the hSWI/SNF chromatin remodeling complex, is often mutated or deleted in malignant rhabdoid tumor (MRT). Two isoforms of INI-1, that differ by the variable inclusion of amino acids, potentially are produced by differential RNA splicing. The morphology of MRTs can present challenges in differential diagnosis. The overall survival of MRTs relative to its potential mimics (medulloblastoma, supratentorial primitive neuroectodermal tumors (sPNETs) is quite low, and thus differentiation from these other tumors is desirable. Lack of nuclear labeling by anti-INI-1 is characteristic of MRT. The majority of medulloblastomas and sPNETs are labeled by anti-INI-1. MRTs also originate from the kidney and soft tissues.
For an antibody with protein microarray specificity validation, see our INI1 Antibody SMARCB1/3984.
Optimal dilution of the SMARCB1 Antibody rSMARCB1/4588 / Integrase interactor 1 Monoclonal Antibody should be determined by the researcher.
A portion of amino acids 257-359 was used as the immunogen for the SMARCB1 Antibody rSMARCB1/4588.
Aliquot the SMARCB1 Antibody rSMARCB1/4588 and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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