- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
SMARCB1 Monoclonal Antibody INI1/8935R / Integrase interactor 1 Rabbit MAb [clone INI1/8935R] (V4863)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V4863-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
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V4863-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
|
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V4863SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | INI1/8935R |
| Purity | Protein A/G affinity |
| UniProt | Q12824 |
| RRID | AB_3756898 |
| Localization | Nucleus |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This SMARCB1 Antibody INI1/8935R is available for research use only. |
|
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The INI-1 gene, which encodes a functionally uncharacterized protein component of the hSWI/SNF chromatin remodeling complex, is often mutated or deleted in malignant rhabdoid tumor (MRT). Two isoforms of INI-1, that differ by the variable inclusion of amino acids, potentially are produced by differential RNA splicing. The morphology of MRTs can present challenges in differential diagnosis. The overall survival of MRTs relative to its potential mimics (medulloblastoma, supratentorial primitive neuroectodermal tumors (sPNETs) is quite low, and thus differentiation from these other tumors is desirable. Lack of nuclear labeling by anti-INI-1 is characteristic of MRT. The majority of medulloblastomas and sPNETs are labeled by anti-INI-1. MRTs also originate from the kidney and soft tissues.
For an antibody with protein microarray specificity validation, see our INI1 Antibody SMARCB1/3984.
Optimal dilution of the SMARCB1 Antibody INI1/8935R should be determined by the researcher.
Recombinant full-length human SMARCB1 protein was used as the immunogen for the SMARCB1 Antibody INI1/8935R.
Aliquot the SMARCB1 Antibody INI1/8935R and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Integrase Interactor 1 antibody, INI1 antibody, BAF47 antibody, SNF5 antibody, hSNF5 antibody, SNF5L1 antibody, SWI/SNF Complex Subunit SMARCB1 antibody, BRG1-Associated Factor 47 antibody
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