- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Recombinant Thrombomodulin antibody is a valuable reagent for studying thrombomodulin, an endothelial glycoprotein that regulates coagulation and vascular integrity. Thrombomodulin is expressed on the surface of endothelial cells, where it binds thrombin to form a complex that activates protein C. Activated protein C then degrades clotting factors Va and VIIIa, providing an anticoagulant pathway that balances hemostasis. Because of this function, thrombomodulin is central to vascular biology and thrombotic disease research.
In addition to its anticoagulant role, thrombomodulin influences inflammation and tissue repair. Its lectin like domain modulates leukocyte adhesion and cytokine activity, while soluble thrombomodulin fragments circulate in plasma and reflect endothelial health. Altered expression of thrombomodulin is associated with vascular injury, sepsis, and cancer, underscoring its broad physiological significance.
The Recombinant Thrombomodulin antibody clone rTHBD/1591 ensures precise detection of this endothelial receptor. Recombinant production guarantees consistency across lots, reducing variability in experimental outcomes. Clone rTHBD/1591 has been applied in vascular biology to study endothelial function, in hematology to explore coagulation balance, and in oncology to investigate tumor associated changes in thrombomodulin expression. Its specificity supports reproducible research across diverse systems.
Research using this antibody has clarified how thrombomodulin integrates anticoagulation with vascular protection. Deficiencies or mutations in the THBD gene are associated with thrombotic disorders, while increased soluble thrombomodulin levels serve as biomarkers of endothelial injury. Studies with clone rTHBD/1591 continue to provide insights into the interplay between coagulation, inflammation, and vascular pathology.
NSJ Bioreagents offers this Recombinant Thrombomodulin antibody to support investigations into hemostasis, vascular biology, and disease. The protein is also known as THBD antibody, endothelial cell thrombomodulin receptor antibody, CD141 antibody, and anticoagulant glycoprotein antibody, reflecting the variety of terminology used by scientists.
The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the recombinant Thrombomodulin antibody to be titered up or down for optimal performance.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Human recombinant partial protein corresponding to amino acids 69-194 was used as the immunogen for this recombinant Thrombomodulin antibody.
Store the recombinant Thrombomodulin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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