- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
pS2 Antibody Recombinant Mouse MAb rTFF1/1091 / TFF1 Antibody [clone rTFF1/1091] (V8111)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V8111-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
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V8111-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V8111SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG1, kappa |
| Clone Name | rTFF1/1091 |
| Purity | Protein G affinity chromatography |
| UniProt | P04155 |
| Localization | Cytoplasmic |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml (not suitable for frozen tissues) |
| Limitations | This recombinant pS2 antibody is available for research use only. |
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Trefoil factor 1 (TFF1) is a small secreted epithelial peptide encoded by the TFF1 gene and belongs to the trefoil factor family of mucin-associated proteins that help maintain epithelial integrity in the gastrointestinal tract. The protein is most strongly expressed in mucus-secreting epithelial cells of the stomach, particularly within gastric foveolar epithelium where it contributes to stabilization of the mucin layer protecting the gastric mucosa. pS2 Antibody Recombinant Mouse MAb rTFF1/1091 recognizes Trefoil factor 1 protein and supports detection of TFF1 expression in epithelial tissues and experimental cell models used to study mucosal biology and epithelial differentiation. TFF1 antibody, also referred to as Trefoil factor 1 antibody or pS2 antibody in the literature, targets a protein widely used as a marker of gastric epithelial lineage and hormone-responsive epithelial tumors.
The protein was originally identified in breast carcinoma cells as an estrogen inducible secretory peptide known as pS2. Expression of TFF1 is strongly associated with estrogen receptor signaling pathways and is frequently detected in hormone-responsive breast cancer cells. Because of this relationship, pS2 antibody detection has been widely used in studies examining estrogen-regulated gene expression and breast tumor biology. Expression of TFF1 in breast cancer cell lines such as MCF7 reflects the regulatory influence of estrogen signaling on secretory protein production in epithelial tumor cells.
In addition to its role in breast cancer biology, TFF1 plays an important physiological role in maintaining gastrointestinal epithelial integrity. The protein is secreted into the gastric mucus layer where it interacts with mucins and other extracellular components to support stability of the mucosal barrier. Trefoil factor peptides contain a characteristic trefoil domain stabilized by disulfide bonds that allows them to remain structurally stable in the protease-rich environment of the gastrointestinal lumen. These properties enable TFF1 to participate in epithelial restitution processes that promote rapid repair of damaged mucosal surfaces.
TFF1 expression patterns are frequently used to investigate epithelial differentiation and mucosal barrier biology. Strong expression is typically observed in gastric epithelial cells while expression in other tissues is more limited. Alterations in TFF1 expression have also been investigated in studies of gastric tumorigenesis and epithelial transformation, highlighting the role of this trefoil family peptide in maintaining normal epithelial homeostasis.
pS2 Antibody Recombinant Mouse MAb rTFF1/1091 supports research examining Trefoil factor 1 expression in epithelial tissues and tumor cell models. Detection of TFF1 protein allows investigators to study gastric epithelial biology, mucosal barrier regulation, and estrogen-regulated signaling pathways associated with epithelial tumor biology.
Optimal dilution of the pS2 Antibody Recombinant Mouse MAb rTFF1/1091 should be determined by the researcher.
A recombinant full-length human protein was used as the immunogen for this recombinant pS2 antibody. Its epitope is located in the c-terminal region of human pS2 protein.
Store the recombinant pS2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Trefoil factor 1, TFF1, Breast cancer associated protein pS2, Trefoil factor family peptide 1, Trefoil factor peptide 1
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