- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Recombinant Prostate Specific Antigen Antibody / PSA KLK3 Antibody [clone rKLK3/4753] (V8699)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V8699-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
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V8699-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V8699SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG2a, kappa |
| Clone Name | rKLK3/4753 |
| Purity | Protein G affinity chromatography |
| UniProt | P07288 |
| Localization | Cytoplasmic |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT |
| Limitations | This recombinant Prostate Specific Antigen antibody is available for research use only. |
|
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Prostate specific antigen (PSA), encoded by the KLK3 gene, is a glandular serine protease produced predominantly by secretory epithelial cells of the prostate. KLK3 belongs to the kallikrein related peptidase family, a group of closely related proteases involved in extracellular protein processing. Recombinant Prostate Specific Antigen Antibody (clone rKLK3/4753) recognizes the PSA protein and enables detection of KLK3 expression in prostate derived tissues and tumors in studies investigating prostate epithelial differentiation and prostate cancer biology.
PSA plays an important physiological role in male reproductive biology. The protein is synthesized as a preproenzyme in prostate epithelial cells and undergoes several processing steps during secretion. After removal of the signal peptide and activation of the enzyme, PSA is released into the seminal fluid where it cleaves semenogelins and related structural proteins. This enzymatic activity contributes to the liquefaction of seminal coagulum and helps maintain sperm motility following ejaculation.
Within the prostate gland, PSA production is largely confined to luminal epithelial cells that line prostatic acini and ducts. The protein accumulates in the cytoplasm of these secretory cells and is released into the glandular lumen. Because KLK3 expression is tightly restricted to prostate epithelial tissue, PSA has become one of the most characteristic molecular markers associated with prostate gland biology.
In prostate malignancies, PSA expression is commonly maintained in tumor epithelial cells, particularly in prostate adenocarcinoma. Detection of PSA can therefore support research investigating the cellular origin of tumors and the differentiation status of prostate cancer cells. Studies examining PSA expression patterns also contribute to understanding the relationship between prostate epithelial function and tumor development.
A recombinant monoclonal Prostate Specific Antigen antibody such as clone rKLK3/4753 provides a reagent for detecting KLK3 in research applications involving prostate tissue analysis and prostate cancer studies. Detection typically reveals cytoplasmic localization of PSA in prostate epithelial cells and prostate tumor cells consistent with the secretory biology of the PSA protein.
Optimal dilution of the Recombinant Prostate Specific Antigen Antibody clone rKLK3/4753 should be determined by the researcher.
Recombinant full-length human KLK3/PSA protein was used as the immunogen for the recombinant Prostate Specific Antigen antibody.
Store the recombinant Prostate Specific Antigen antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
PSA antibody, KLK3 antibody, Kallikrein related peptidase 3 antibody, Human prostate specific antigen antibody
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