- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Recombinant Prostate Specific Antigen Antibody KLK3/7128R / PSA KLK3 Antibody [clone KLK3/7128R] (V9652)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V9652-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
|
V9652-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
|
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V9652SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | KLK3/7128R |
| Purity | Protein A/G affinity |
| UniProt | P07288 |
| Localization | Secreted |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This Prostate Specific Antigen antibody is available for research use only. |
|
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Prostate specific antigen (KLK3) is a secreted serine protease encoded by the KLK3 gene and produced primarily by luminal epithelial cells of the prostate gland. The protein is widely known as Prostate specific antigen or PSA and is a member of the kallikrein related peptidase family of serine proteases. Recombinant Prostate Specific Antigen Antibody KLK3/7128R recognizes the KLK3 protein and enables detection of PSA expression in studies focused on prostate epithelial biology and prostate cancer.
PSA is synthesized as a precursor enzyme that contains a signal peptide and propeptide sequence that are removed during secretion and activation. The mature enzyme functions in seminal plasma where it cleaves semenogelins and other seminal proteins, promoting liquefaction of seminal coagulum following ejaculation. Because of this specialized physiological role, PSA expression is largely restricted to prostate epithelial cells under normal biological conditions.
Within prostate tissue, KLK3 protein is typically localized to luminal epithelial cells that line prostatic glands and ducts. These cells actively synthesize and secrete PSA into glandular lumina, reflecting the functional role of the prostate in seminal fluid production. The restricted cellular distribution of PSA has made it one of the most widely studied markers of prostate epithelial differentiation.
PSA expression is commonly retained in prostate adenocarcinoma and in metastatic tumors originating from the prostate. Detection of KLK3 expression is therefore frequently used in studies examining prostate tumor biology, epithelial differentiation, and the lineage origin of prostate derived malignancies. Analysis of PSA expression patterns provides insight into prostate tumor progression and the biological behavior of prostate cancer cells.
Recombinant Prostate Specific Antigen Antibody KLK3/7128R provides a reagent for detecting KLK3 protein in studies of prostate tissue biology and prostate cancer models. Recombinant monoclonal antibodies recognize a defined epitope within the target protein, allowing consistent recognition of PSA while supporting investigation of KLK3 protein expression in molecular and cellular research systems.
Optimal dilution of the Recombinant Prostate Specific Antigen Antibody KLK3/7128R should be determined by the researcher.
A portion of amino acids 150-250 was used as the immunogen for the recombinant Prostate Specific Antigen antibody.
Aliquot the recombinant Prostate Specific Antigen antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
PSA antibody, KLK3 antibody, Prostate specific antigen antibody, Kallikrein related peptidase 3 antibody
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