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Home >> Antibodies >> Recombinant PDCD1 Antibody / PD-1 / PD1

Recombinant PDCD1 Antibody / PD-1 / PD1 [clone PDCD1/7125] (V4042)

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  Catalog No Formulation Size Price (USD)  
Image V4042-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 539
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V4042-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 249
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V4042SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 539
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Western blot testing of human tonsil and brain tissue lysate with recombinant PDCD1 antibody. Predicted molecular weight: 32-55 kDa depending on glycosylation level.
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Western blot testing of human tonsil and brain tissue lysate with recombinant PDCD1 antibody. Predicted molecular weight: 32-55 kDa depending on glycosylation level.
IHC staining of FFPE human tonsil tissue with recombinant PDCD1 antibody (clone PDCD1/7125). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
Negative control: IHC staining of FFPE human skin tissue with recombinant PDCD1 antibody (clone PDCD1/7125). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
SDS-PAGE analysis of purified, BSA-free recombinant PDCD1 antibody (clone PDCD1/7125) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1, kappa
Clone Name PDCD1/7125
Purity Protein A/G affinity
UniProt Q15116
Localization Cell surface, cytoplasm
Applications Western Blot : 2-4ug/ml
Immunohistochemistry (FFPE) : 1-2ug/ml
Limitations This recombinant PDCD1 antibody is available for research use only.
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Description

PDCD-1 (programmed cell death-1 protein), also designated CD279, is a type I transmembrane receptor and a member of the immunoglobin gene superfamily. It is expressed on activated T-cells, B-cells, and myeloid cells. Anti-PDCD-1 is a marker of angioimmunoblastic lymphoma and suggests a unique cell of origin for this neoplasm. Unlike CD10 and BCL6, PDCD-1 is expressed by few B-cells, so anti-PDCD-1 may be a more specific and useful diagnostic marker in angioimmunoblastic lymphoma. In addition, PDCD-1 expression provides evidence that angioimmunoblastic lymphoma is a neoplasm derived from germinal center-associated T-cells.

Application Notes

Optimal dilution of the recombinant PDCD1 antibody should be determined by the researcher.

Immunogen

A portion of amino acids 1-200 from the human protein was used as the immunogen for the recombinant PDCD1 antibody.

Storage

Aliquot the recombinant PDCD1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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