- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
p40 Antibody for IF / deltaNp63 Immunofluorescence Antibody [clone TP40/3980R] (V8628)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V8628-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
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|
V8628-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V8628SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | TP40/3980R |
| Purity | Protein A affinity chromatography |
| UniProt | Q9H3D4 |
| Localization | Nuclear |
| Applications | Flow Cytometry : 1-2ug/million cells Immunofluorescence : 1-2ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT |
| Limitations | This p40 antibody is available for research use only. |
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Tumor protein p40, representing the deltaNp63 isoform of TP63, is a nuclear transcription factor that regulates epithelial differentiation and maintains squamous and basal epithelial identity. p40 Antibody for IF is optimized for immunofluorescence applications where high-resolution imaging, nuclear localization, and co-localization analysis are central to interpretation. This format allows researchers to directly visualize deltaNp63 within individual cells and in relation to other cellular structures.
p40 antibody, also known as deltaNp63 antibody in the literature, is highly specific for the deltaNp63 isoform and provides a more focused signal than broader p63 antibodies. In immunofluorescence, this specificity is particularly important because it ensures that nuclear staining reflects lineage-relevant deltaNp63 expression rather than mixed isoform detection. p40 Antibody for IF enables clear identification of deltaNp63-positive nuclei within epithelial sheets, basal layers, and tumor cell populations.
The IF differentiator is especially strong because immunofluorescence preserves spatial and subcellular context while enabling multiplex detection. p40 Antibody for IF produces a confined nuclear fluorescence signal that can be directly compared with cytoplasmic, membrane, or proliferation markers in the same sample. This allows researchers to study how deltaNp63 expression relates to cell state, differentiation status, and interactions with other signaling pathways.
Clone TP40/3980R is a recombinant rabbit monoclonal antibody, providing high affinity and strong signal intensity. In fluorescence-based applications, this often results in bright, well-defined nuclear staining with low background. The recombinant format ensures consistent performance across experiments, which is essential for imaging workflows where signal quality directly affects interpretation and reproducibility.
In cell and tissue imaging, p40 Antibody for IF enables visualization of heterogeneity within epithelial populations, allowing researchers to distinguish strongly positive, weakly positive, and negative cells within the same field. This is particularly useful in studies of tumor biology, where differences in deltaNp63 expression may reflect distinct cellular states or differentiation stages.
The ability to combine p40 staining with multiple fluorescent channels further enhances its utility. Researchers can perform co-localization studies to evaluate relationships between deltaNp63 and other nuclear or cytoplasmic markers, providing deeper insight into epithelial organization and transcriptional regulation.
p40 Antibody for IF is particularly valuable for applications requiring precise nuclear localization, high-resolution imaging, and multiplex analysis. Its deltaNp63 specificity ensures accurate interpretation of lineage-associated expression, while the rabbit monoclonal format supports strong and consistent fluorescence signal.
Tumor protein p40 antibody clone TP40/3980R provides a high-performance solution for immunofluorescence detection of deltaNp63, enabling detailed analysis of nuclear localization, epithelial differentiation, and cellular heterogeneity.
Optimal dilution of the recombinant p40 Antibody for IF / deltaNp63 Immunofluorescence Antibody should be determined by the researcher.
A synthetic peptide from the N-terminal of human p40 protein was used as the immunogen for the p40 Antibody for IF / deltaNp63 Immunofluorescence Antibody.
Store the recombinant p40 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
p40 immunofluorescence antibody, deltaNp63 IF antibody, p40 nuclear fluorescence antibody, deltaNp63 cell imaging antibody
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