- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Recombinant MUC6 Antibody / Gastric Mucin / Rabbit Monoclonal [clone MUCN6-2R] (V3682)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V3682-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
|
|
V3682-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
|
|
V3682SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 | |
|
|
V3682IHC-7ML | Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only* | 7 ml | 559 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | MUCN6-2R |
| Purity | Protein A affinity chromatography |
| UniProt | Q6W4X9 |
| Localization | Cytoplasmic & secreted |
| Applications | Immunohistochemistry (FFPE) : 2-4ug/ml for 30 min at RT Prediluted IHC Only Format : incubate for 30 min at RT (1) |
| Limitations | This MUC6 antibody is available for research use only. |
|
Review this product on BioCompare and get a $20 Amazon gift card
|
Related Products
|
MUC6 antibody (clone MUCN6-2R) targets Mucin 6, a secreted gel-forming mucin encoded by the human MUC6 gene and a key component of gastric gland mucus. Mucin 6, also widely referred to as MUC6 in the literature, is predominantly expressed in pyloric glands of the stomach and in Brunner glands of the duodenum. MUC6 antibody clone MUCN6-2R is a recombinant monoclonal antibody developed for consistent detection of Mucin 6 expression in glandular epithelial tissues.
MUC6 is synthesized as a large, heavily O-glycosylated secreted glycoprotein that polymerizes to form part of the protective mucus barrier within the gastrointestinal tract. In normal gastric mucosa, Mucin 6 is localized to the cytoplasm and secretory granules of deep glandular epithelial cells, whereas MUC5AC marks the surface foveolar epithelium. This zonal expression pattern makes MUC6 antibody particularly valuable for distinguishing gastric gland differentiation and for evaluating mucin phenotype shifts in intestinal metaplasia and gastric carcinoma.
Aberrant expression of MUC6 has been reported in gastric adenocarcinoma, pancreatic neoplasms, and colorectal tumors demonstrating gastric-type differentiation. Altered Mucin 6 distribution is also observed in preneoplastic lesions and metaplastic changes. MUC6 antibody clone MUCN6-2R supports immunohistochemical assessment of pyloric-type mucin production and glandular lineage profiling in research applications.
Structurally, Mucin 6 contains extensive tandem repeat domains rich in serine and threonine residues that enable dense O-glycosylation, along with cysteine-rich domains responsible for mucin polymerization and gel formation. As a recombinant monoclonal antibody, clone MUCN6-2R provides defined sequence consistency for detecting MUC6 expression in gastric glands, duodenal Brunner glands, and mucin-producing glandular tissues in research settings.
The stated application concentrations are suggested starting points. Titration of the MUC6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
A peptide from the Mucin-6 tandem repeat sequence was used as the immunogen for the MUC6 antibody.
Store the recombinant MUC6 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.
Powered by Bioz
Citations(10)