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Mammaglobin A (SCGB2A2) is a secreted epithelial glycoprotein encoded by the SCGB2A2 gene and belongs to the secretoglobin family of small secreted proteins associated with mammary epithelial differentiation. Recombinant Mammaglobin A Antibody MMGA-1R recognizes Mammaglobin A / SCGB2A2 and targets a protein widely studied as a marker of mammary epithelial cells and breast carcinoma.
Mammaglobin antibody, also referred to as Mammaglobin A antibody or SCGB2A2 antibody in the literature, detects a protein predominantly produced by luminal epithelial cells of the mammary gland. Mammaglobin A is secreted into glandular lumens as part of normal epithelial secretory activity within mammary tissue. Because of this relatively restricted tissue distribution, Mammaglobin expression has been extensively examined in studies of mammary gland biology and breast tumor origin.
Structurally, Mammaglobin A contains conserved cysteine residues characteristic of secretoglobin family proteins that contribute to stable folding within epithelial secretory pathways. As a secreted epithelial protein, Mammaglobin is typically detected within the cytoplasm of mammary epithelial cells and may also be present within glandular luminal secretions depending on tissue architecture and experimental preparation. These localization characteristics reflect the role of Mammaglobin A in epithelial secretory processes within the mammary gland.
Expression of Mammaglobin A is frequently observed in breast epithelial cells and breast carcinoma specimens, where it reflects the differentiated state of mammary epithelial tumor cells. In breast tumors, Mammaglobin expression is often detected within epithelial tumor cell populations forming glandular structures, while surrounding stromal cells and connective tissue components generally show little to no staining. These expression patterns have made Mammaglobin a valuable marker in breast cancer research and epithelial tumor characterization.
Recombinant Mammaglobin A Antibody (clone MMGA-1R) is a rabbit monoclonal antibody developed to detect Mammaglobin A / SCGB2A2 in studies of mammary epithelial biology, tumor differentiation, and protein expression patterns in breast tissue and breast cancer research models.
The stated application concentrations are suggested starting points. Titration of the Recombinant Mammaglobin A Antibody MMGA-1R may be required due to differences in protocols and secondary/substrate sensitivity.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Full length recombinant human protein was used as the immunogen for the recombinant Mammaglobin A antibody.
Store the recombinant Mammaglobin A antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Mammaglobin antibody, Mammaglobin A antibody, SCGB2A2 antibody, Secretoglobin family 2A member 2 antibody, Mammary gland secretoglobin antibody
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