- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Recombinant Kappa Light Chain antibody recognizes the kappa light chain of immunoglobulins, a structural element critical for antibody function. Light chains pair with heavy chains to create antigen-binding fragments, conferring the specificity that defines adaptive immunity. Kappa chains are produced by B lymphocytes during immunoglobulin assembly, and the ratio of kappa to lambda light chains serves as a diagnostic marker in both health and disease.
The structure of the kappa light chain consists of one variable domain and one constant domain. The variable domain forms part of the antigen binding site, enabling precise recognition of diverse antigens. The constant domain contributes to antibody stability and flexibility. Kappa light chains are encoded by genes that undergo VJ recombination, adding to antibody diversity. Free kappa chains appear in serum and urine when immunoglobulin synthesis is dysregulated, providing a biomarker for plasma cell disorders.
The Recombinant Kappa Light Chain antibody clone rL1C1 provides precise and reproducible detection. Recombinant engineering ensures consistent performance across experimental systems. Clone rL1C1 has been used in studies of immunoglobulin gene rearrangement, plasma cell dyscrasias, and B cell development. Peer-reviewed research highlights the relevance of kappa chain detection in evaluating monoclonal gammopathies and distinguishing between clonal and reactive processes.
Applications of clone rL1C1 include identification of B cell malignancies such as multiple myeloma and lymphoma, monitoring disease progression, and contributing to research on antibody structure. The antibody supports investigation into light chain regulation and its role in immune system balance. Its specificity provides confidence for both laboratory and translational research applications.
NSJ Bioreagents offers this Recombinant Kappa Light Chain antibody to enable high-quality studies of immunoglobulin biology and disease. The protein is also known as Ig kappa chain antibody, kappa immunoglobulin light chain antibody, free kappa antibody, and immunoglobulin variable kappa region antibody. These alternate designations demonstrate the wide scope of kappa chain research in immunology and pathology.
The optimal dilution of the recombinant Kappa Light Chain antibody for each application should be determined by the researcher.
Recombinant human Ig kappa chain was used as the immunogen for this recombinant Kappa Light Chain antibody.
Store the recombinant Kappa Light Chain antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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