- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Recombinant IBA1 antibody is a highly specific reagent for detecting ionized calcium-binding adaptor molecule 1, also known as AIF1. Encoded by the AIF1 gene, IBA1 is expressed primarily in microglia, macrophages, and other myeloid-lineage cells. It is a cytoplasmic protein that regulates actin dynamics, membrane ruffling, and phagocytosis. Because of its cell-type specificity and functional importance, IBA1 is widely used as a marker for microglia and macrophages in neuroscience and immunology.
IBA1 contributes to immune cell activation by binding actin and promoting cytoskeletal reorganization. It is essential for processes such as migration, motility, and phagocytosis, which enable microglia and macrophages to respond to injury and infection. In the nervous system, IBA1 expression is upregulated during neuroinflammation, making it a valuable marker for brain pathology. In immunology, IBA1 detection supports studies of macrophage biology and innate immunity.
The Recombinant IBA1 antibody clone rAIF1/1909 provides reliable and consistent recognition of this actin-binding protein. Recombinant technology guarantees batch-to-batch uniformity, reducing experimental variability. Clone rAIF1/1909 has been employed in studies of neuroinflammation, microglial activation, and macrophage function. Peer-reviewed publications have reported use of this clone in models of neurodegeneration and inflammatory disease, validating its importance in neuroscience research.
Research with clone rAIF1/1909 has clarified how IBA1 expression correlates with microglial activation states in conditions such as Alzheimer disease, Parkinson disease, and multiple sclerosis. In immunology, it has been used to investigate macrophage responses during infection and tissue repair. This antibody remains indispensable for exploring how innate immune cells contribute to both homeostasis and disease.
NSJ Bioreagents provides this Recombinant IBA1 antibody to support high-quality research in neurobiology and immunology. The protein is also described as AIF1 antibody, ionized calcium-binding adaptor 1 antibody, macrophage activation factor antibody, and microglia marker antibody, reflecting the multiple terms used in scientific contexts.
Titering of the recombinant IBA1 antibody may be required for optimal performance.
A portion of amino acids 1-146 from the human protein was used as the immunogen for the recombinant IBA1 antibody.
Store the recombinant IBA1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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