- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Recombinant GNRHR Antibody GNRHR/2982R / GnRH Receptor Rabbit Monoclonal Antibody [clone GNRHR/2982R] (V7814)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V7814-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
|
|
V7814-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
|
|
V7814SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
|
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | GNRHR/2982R |
| Purity | Protein A affinity chromatography |
| UniProt | P30968 |
| Applications | |
| Limitations | This Recombinant GNRHR Antibody GNRHR/2982R / GnRH Receptor Rabbit Monoclonal Antibody is available for research use only. |
|
Review this product on BioCompare and get a $20 Amazon gift card
|
Related Products
|
Recombinant GNRHR Antibody GNRHR/2982R / GnRH Receptor Rabbit Monoclonal Antibody recognizes the gonadotropin-releasing hormone receptor, a member of the rhodopsin-like G protein-coupled receptor family encoded by the GNRHR gene. Also known as the gonadoliberin receptor or luteinizing hormone-releasing hormone receptor, GNRHR mediates the effects of gonadotropin-releasing hormone (GnRH), a hypothalamic peptide that coordinates reproductive endocrine activity. The receptor is primarily expressed by gonadotroph cells in the anterior pituitary, where its activation regulates the synthesis and secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
GNRHR contains seven transmembrane domains characteristic of G protein-coupled receptors. Binding of GnRH activates signaling primarily through Gq/11 proteins, stimulating phospholipase C beta and generating inositol trisphosphate and diacylglycerol. These second messengers promote intracellular calcium mobilization and protein kinase C activation, contributing to gonadotropin secretion and transcriptional regulation. Additional signaling through mitogen-activated protein kinase pathways influences gene expression and cellular responses to hormonal stimulation.
A distinctive feature of the mammalian type I GnRH receptor is its lack of a conventional intracellular C-terminal tail. This structural characteristic influences receptor internalization, desensitization, and intracellular signaling regulation. Physiological GnRH secretion occurs in pulses, with stimulation frequency affecting the relative production of LH and FSH. Sustained receptor stimulation can produce adaptive changes that suppress gonadotropin secretion, illustrating the importance of temporal signaling patterns in reproductive endocrine regulation.
GNRHR function is essential for normal sexual maturation and fertility. Inactivating variants in the receptor gene are associated with congenital hypogonadotropic hypogonadism, a condition involving deficient gonadotropin secretion and impaired reproductive development. Disease-associated mutations can affect receptor folding, membrane trafficking, ligand recognition, or downstream signaling. Studies of these variants have helped clarify relationships between receptor structure, cell-surface expression, and endocrine responsiveness.
Beyond the anterior pituitary, GNRHR expression has been investigated in reproductive tissues and several hormone-associated malignancies. Research involving ovarian, endometrial, and breast cancer models has explored potential relationships between GnRH receptor signaling, cellular proliferation, and responses to GnRH analogs. These findings remain dependent on biological context and experimental validation. NSJ Bioreagents offers this Recombinant GNRHR Antibody to support investigations of receptor expression, neuroendocrine communication, reproductive hormone regulation, and the molecular mechanisms underlying GnRH-dependent signaling.
For additional GNRHR research, explore our GnRH Receptor Antibody F1G4, a monoclonal antibody associated with published studies investigating GnRH receptor expression and signaling.
Optimal dilution of the Recombinant GNRHR Antibody GNRHR/2982R / GnRH Receptor Rabbit Monoclonal Antibody should be determined by the researcher.
Recombinant full-length human GNRHR protein was used as the immunogen for this recombinant GNRHR / LHCGR antibody.
Store the recombinant GNRHR / LHCGR antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Recombinant GnRH receptor antibody, Recombinant gonadotropin-releasing hormone receptor antibody, Recombinant gonadoliberin receptor antibody, Recombinant LH-RH receptor antibody
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.
Powered by Bioz
Citations(5)
