- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Gastric Mucin/MUC6 Antibody [clone MUC6/1553R] (V3722)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V3722-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
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V3722-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V3722SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 | |
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V3722IHC-7ML | Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only* | 7 ml | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | MUC6/1553R |
| Purity | Protein A affinity chromatography |
| UniProt | Q6W4X9 |
| Localization | Cytoplasmic & secreted |
| Applications | Immunohistochemistry (FFPE) : 2-4ug/ml for 30 min at RT (1) |
| Limitations | This Gastric Mucin/MUC6 antibody is available for research use only. |
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Gastric Mucin antibody (clone MUC6/1553R) targets Mucin 6, a secreted gel-forming mucin encoded by the human MUC6 gene and a principal component of deep gastric gland mucus. Mucin 6, also widely referred to as MUC6 in molecular and pathology literature, is predominantly expressed in pyloric glands of the stomach and in Brunner glands of the duodenum. Because of this restricted localization, Gastric Mucin antibody and MUC6 antibody are commonly used in studies evaluating pyloric-type differentiation and gastric gland lineage in normal and neoplastic tissues.
MUC6 is synthesized as a large, heavily O-glycosylated secreted glycoprotein that polymerizes to form part of the protective mucus barrier in the gastrointestinal tract. In normal gastric mucosa, Mucin 6 is localized to the cytoplasm and secretory granules of deep glandular epithelial cells, whereas MUC5AC marks the superficial foveolar epithelium. This complementary zonal expression pattern makes Gastric Mucin antibody clone MUC6/1553R particularly useful for distinguishing glandular compartments and assessing mucin phenotype shifts in metaplasia and carcinoma.
Altered MUC6 expression has been documented in gastric adenocarcinoma, pancreatic neoplasms, and colorectal tumors demonstrating gastric-type differentiation. Changes in Mucin 6 distribution are also observed in intestinal metaplasia and other preneoplastic conditions. Gastric Mucin antibody supports immunohistochemical characterization of pyloric gland differentiation and mucin subclass profiling in research applications.
Structurally, Mucin 6 contains extensive tandem repeat domains enriched in serine and threonine residues that support dense O-glycosylation, along with cysteine-rich domains responsible for mucin polymerization and gel formation. A Gastric Mucin antibody such as clone MUC6/1553R is suitable for detecting MUC6 expression in gastric glands, duodenal Brunner glands, and mucin-producing glandular tissues in research settings.
Optimal dilution of the Gastric Mucin/MUC6 antibody should be determined by the researcher.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
A peptide from the MUC6 tandem repeat sequence was used as the immunogen for the Gastric Mucin/MUC6 antibody.
Store the Gastric Mucin/MUC6 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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