- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Recombinant Filaggrin Antibody rFLG/1561 / Recombinant FLG Monoclonal Antibody [clone rFLG/1561] (V3611)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V3611-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
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V3611-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V3611SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 | |
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V3611IHC-7ML | Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only* | 7 ml | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG1, kappa |
| Clone Name | rFLG/1561 |
| Purity | Protein G affinity chromatography |
| UniProt | P20930 |
| Localization | Cytoplasmic |
| Applications | Immunohistochemistry (FFPE) : 0.5-1ug/ml for 30 min at RT |
| Limitations | This Recombinant Filaggrin Antibody rFLG/1561 / Recombinant FLG Monoclonal Antibody is available for research use only. |
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Recombinant Filaggrin Antibody rFLG/1561 / Recombinant FLG Monoclonal Antibody detects Filaggrin (FLG), an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple Filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional Filaggrin molecules. Active Filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery.
Explore our Filaggrin Antibody / Epidermal Differentiation Marker page for additional validation data and research applications involving keratinocyte maturation, epithelial barrier biology, and dermatopathology-associated signaling pathways.
Optimal dilution of the Recombinant Filaggrin Antibody rFLG/1561 / Recombinant FLG Monoclonal Antibody should be determined by the researcher.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Amino acids 198-288 of human FLG were used as the immunogen for this Recombinant Filaggrin Antibody rFLG/1561.
Store the Recombinant Filaggrin Antibody rFLG/1561 at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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