- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
ECM1 Antibody / Extracellular Matrix Organization and Secreted Glycoprotein Marker [clone ECM1/2889R] (V3979)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V3979-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
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V3979-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V3979SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 | |
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V3979IHC-7ML | Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only* | 7 ml | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | ECM1/2889R |
| Purity | Protein A affinity chromatography |
| UniProt | Q16610 |
| Localization | Cell surface and cytoplasmic |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This ECM1 Antibody / Extracellular Matrix Organization and Secreted Glycoprotein Marker is available for research use only. |
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Extracellular matrix protein 1 (ECM1) is a secreted glycoprotein that plays a central role in extracellular matrix organization, cell signaling, and tissue homeostasis. ECM1 Antibody, clone ECM1/2889R, is a recombinant rabbit monoclonal antibody designed to detect this multifunctional protein in studies of epithelial biology, stromal interactions, and disease-associated tissue remodeling.
ECM1 is widely expressed in epithelial cells, endothelial cells, and various stromal populations, where it is secreted into the extracellular space and associates with structural components of the matrix. It interacts with proteins such as laminin, fibulin, and perlecan, contributing to the organization and stability of basement membranes and interstitial matrix structures. Through these interactions, ECM1 helps regulate cell adhesion, differentiation, and communication within tissues.
In addition to its structural role, ECM1 participates in signaling processes that influence cell proliferation, angiogenesis, and inflammatory responses. Its presence in the extracellular environment allows it to modulate interactions between cells and their surrounding matrix, making it an important mediator of tissue architecture and microenvironment dynamics. ECM1 has also been linked to regulation of protease activity, further contributing to matrix remodeling and cellular migration.
ECM1 expression has been implicated in a variety of pathological conditions, including cancer, fibrosis, and inflammatory disorders. In tumor biology, elevated ECM1 levels have been associated with increased invasion, metastasis, and angiogenesis, reflecting its role in shaping the tumor microenvironment. Its expression in both tumor cells and surrounding stromal compartments highlights its importance in coordinating complex cellular interactions during disease progression.
At the molecular level, ECM1 is subject to glycosylation and processing, which can influence its stability, secretion, and interaction with binding partners. It is typically detected as a secreted protein but may also be observed in cytoplasmic compartments during synthesis and trafficking. ECM1 exists in multiple isoforms generated through alternative splicing, which may differ in their binding interactions and tissue distribution. These variants contribute to the diverse functional roles of ECM1 across different tissue environments. Mutations in ECM1 are associated with lipoid proteinosis, a rare genetic disorder characterized by abnormal deposition of extracellular matrix components in the skin and mucosa, underscoring its importance in maintaining normal tissue structure. In addition, ECM1 has been linked to regulation of protease activity and angiogenic signaling, further supporting its role in coordinating extracellular matrix remodeling and microenvironment dynamics in both normal physiology and disease.
This antibody is part of a broader antibody panel offered by NSJ Bioreagents.
Optimal dilution of the ECM1 Antibody / Extracellular Matrix Organization and Secreted Glycoprotein Marker should be determined by the researcher.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Recombinant human protein was used as the immunogen for the recombinant ECM1 antibody.
Store the ECM1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
ECM1 antibody, Extracellular matrix protein 1 antibody, Secretory component glycoprotein antibody, SCG antibody, ECM protein 1 antibody, clone ECM1/2889R antibody
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