- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Recombinant E-Cadherin antibody is used to detect E-Cadherin, a calcium dependent adhesion glycoprotein encoded by the CDH1 gene. E-Cadherin is a core component of adherens junctions, where it mediates homophilic cell cell adhesion and maintains epithelial integrity. It is expressed widely in epithelial tissues and plays a central role in development, morphogenesis, and cancer biology. Because of its critical function, E-Cadherin is studied extensively in cell biology and oncology.
The protein consists of extracellular cadherin repeats, a transmembrane region, and a cytoplasmic tail that binds catenins, linking adhesion complexes to the actin cytoskeleton. This structural organization enables E-Cadherin to stabilize tissue architecture and transmit signals that regulate cell polarity and differentiation. Loss or reduction of E-Cadherin expression disrupts epithelial cohesion and is a hallmark of epithelial to mesenchymal transition, a process that facilitates tumor invasion and metastasis.
The Recombinant E-Cadherin antibody clone rCDH1/1525 provides specific and reproducible recognition of this adhesion molecule. Recombinant production ensures consistency across lots, reducing experimental variability. Clone rCDH1/1525 has been employed in developmental biology to track epithelial morphogenesis and in cancer research to investigate mechanisms of metastasis. Its ability to highlight adherens junctions supports high resolution analysis of tissue structure.
Research using clone rCDH1/1525 has clarified how E-Cadherin regulates adhesion, signaling, and epithelial identity. Altered expression is associated with gastric, breast, ovarian, and colorectal cancers, where it correlates with prognosis and treatment outcomes. Beyond oncology, E-Cadherin detection informs regenerative medicine and developmental biology, where epithelial cohesion is essential for tissue organization.
NSJ Bioreagents provides this Recombinant E-Cadherin antibody to support studies in cell adhesion and cancer. The protein is also known as CDH1 antibody, cadherin 1 antibody, epithelial cadherin antibody, and uvomorulin antibody, highlighting the alternate names used in scientific literature.
Optimal dilution of the recombinant E-Cadherin antibody should be determined by the researcher.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
A full length recombinant human protein was used as the immunogen for the recombinant E-Cadherin antibody.
Store the recombinant E-Cadherin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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