- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Recombinant CNN1 Antibody / Calponin-1 [clone rCNN1/9164] (V5560)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V5560-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
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V5560-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V5560SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG2b, kappa |
| Clone Name | rCNN1/9164 |
| Purity | Protein A/G affinity |
| UniProt | P51911 |
| Localization | Cytoplasm |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This recombinant CNN1 antibody is available for research use only. |
|
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Recombinant CNN1 antibody recognizes Calponin-1, an actin-binding protein encoded by the CNN1 gene and a well-established marker of smooth muscle differentiation. Recombinant CNN1 Antibody (clone rCNN1/9164) is a mouse monoclonal antibody generated through recombinant expression to support consistent performance and lot-to-lot reproducibility in research applications. Calponin-1 localizes predominantly to the cytoplasm of smooth muscle cells, where it associates with actin filaments and regulates contractile activity and cytoskeletal organization.
CNN1 antibody, also referred to as Calponin-1 antibody and basic calponin antibody in the literature, targets a member of the calponin family of actin-binding proteins. Calponin-1 contains calponin homology domains and actin-binding regions that enable interaction with actin, tropomyosin, and other cytoskeletal proteins. Through these interactions, Calponin-1 modulates actomyosin ATPase activity and contributes to maintenance of the contractile phenotype in differentiated smooth muscle cells.
CNN1 expression is characteristic of vascular smooth muscle, gastrointestinal smooth muscle, uterine smooth muscle, and myoepithelial cells of glandular tissues such as breast and salivary gland. The expected immunohistochemical pattern is cytoplasmic staining in smooth muscle layers and myoepithelial cell populations. Because of this lineage-restricted distribution, Calponin-1 serves as a reliable research marker for identifying smooth muscle and myoepithelial differentiation in normal tissues.
In tumor biology research, Calponin-1 expression is frequently evaluated in studies of leiomyoma, leiomyosarcoma, myoepithelial tumors, and other mesenchymal neoplasms. Cytoplasmic staining supports smooth muscle or myoepithelial lineage, whereas most epithelial carcinomas and non-mesenchymal malignancies demonstrate limited or absent expression. Recombinant CNN1 Antibody (clone rCNN1/9164) enables reliable detection of Calponin-1 expression patterns in normal and neoplastic tissues for research use at NSJ Bioreagents.
Optimal dilution of the recombinant CNN1 antibody should be determined by the researcher.
A recombinant fragment (within amino acids 1-200) of human CNN1 protein was used as the immunogen for the recombinant CNN1 antibody.
Aliquot the recombinant CNN1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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