- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Recombinant Chromogranin A antibody is used to detect chromogranin A, a secretory glycoprotein stored in the dense core granules of neuroendocrine cells. Encoded by the CHGA gene, chromogranin A is widely expressed in endocrine tissues such as the adrenal medulla, pancreas, and gastrointestinal tract. It plays roles in hormone packaging, secretion, and regulation of neuroendocrine signaling. Because of its broad distribution, chromogranin A is a cornerstone marker for neuroendocrine differentiation.
Chromogranin A is processed into several biologically active peptides, including vasostatin, pancreastatin, and catestatin. These fragments influence cardiovascular regulation, glucose metabolism, and neurotransmission. Elevated chromogranin A levels in circulation serve as biomarkers for neuroendocrine tumors, making it clinically valuable in oncology. Its biology spans multiple systems, integrating endocrinology, metabolism, and disease pathology.
The Recombinant Chromogranin A antibody clone rCHGA/413 provides consistent and specific recognition. Recombinant technology ensures reproducibility and reduces lot to lot variation. Clone rCHGA/413 has been employed in pathology to identify neuroendocrine tumors, in endocrinology to explore hormone storage, and in neuroscience to examine neuropeptide regulation. Its versatility makes it useful across diverse fields of research.
Studies using clone rCHGA/413 have clarified how chromogranin A supports granule biogenesis and secretion. Its role as a tumor marker has been particularly important, as detection helps diagnose and monitor neuroendocrine tumors including pheochromocytoma, paraganglioma, and carcinoid tumors. This antibody continues to aid both basic science and translational applications.
NSJ Bioreagents offers this Recombinant Chromogranin A antibody to support studies in neuroendocrine biology and cancer. The protein is also described as CHGA antibody, secretory granule protein antibody, parathyroid secretory protein 1 antibody, and neuroendocrine tumor marker antibody, reflecting the varied terminology in the literature.
Optimal dilution of the recombinant Chromogranin A antibody should be determined by the researcher.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Recombinant human protein was used as the immunogen for the recombinant Chromogranin A antibody.
Store the recombinant Chromogranin A antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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