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Home >> Antibodies >> Rage Antibody

Rage Antibody (F43706)

  Catalog No Formulation Size Price (USD)  
Image F43706-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 399
Image
F43706-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 185
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Rage antibody western blot analysis in NCI-H292 lysate. Predicted molecular weight: 45-55kDa depending on glycosylation level.
Rage antibody western blot analysis in mouse Neuro-2a lysate. Predicted molecular weight: 45-55kDa depending on glycosylation level.
Western blot analysis of Rage antibody and 293 cell lysate (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (2) with the mouse Rage gene.
Availability 1-3 business days
Species Reactivity Human, Mouse
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt Q9WVS4
Applications Western blot : 1:1000
Limitations This Rage antibody is available for research use only.
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Description

RAGE, the 'receptor for advanced glycation endproducts' is a transmembrane receptor of the immunoglobulin super family. The interaction between RAGE and its ligands, AGE and HMGB1, is thought to result in pro-inflammatory gene activation. Due to an enhanced level of RAGE ligands in diabetes or other chronic disorders, this receptor is hypothesised to have a causative effect in a range of inflammatory diseases such as diabetic complications, Alzheimer's disease and even some tumors. [Wiki]

Application Notes

Titration of the Rage antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 76-104 from the mouse protein was used as the immunogen for this Rage antibody.

Storage

Aliquot the Rage antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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