- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
PA2.26 Antigen Antibody / Podoplanin Glycoprotein Marker [clone PDPN/8950R] (V4702)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V4702-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V4702-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V4702SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | PDPN/8950R |
| Purity | Protein A/G affinity |
| UniProt | Q86YL7 |
| Localization | Cell surface |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT Western Blot : 2-4ug/ml |
| Limitations | This PA2.26 Antigen Antibody / Podoplanin Glycoprotein Marker is available for research use only. |
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PA2.26 Antigen Antibody / Podoplanin Glycoprotein Marker detects podoplanin (PDPN), a heavily glycosylated cell-surface protein also known as PA2.26 antigen, Gp36 and T1 alpha. Podoplanin is a mucin-type transmembrane glycoprotein expressed by lymphatic endothelial cells and several other specialized cell populations. Extensive post-translational glycosylation contributes to an observed molecular weight of approximately 38-43 kDa despite the smaller predicted molecular weight of the polypeptide.
Podoplanin is a type I transmembrane protein with a heavily O-glycosylated extracellular region and a short cytoplasmic tail. Although PDPN lacks intrinsic enzymatic activity, interactions involving its extracellular and intracellular domains can influence cell morphology, adhesion and migration. Podoplanin also binds the platelet receptor CLEC-2, an interaction important to platelet activation and the proper separation of developing blood and lymphatic vascular systems.
PA2.26 antigen is strongly associated with lymphatic endothelial biology. Podoplanin expression can be used to investigate lymphatic vessels, lymphatic endothelial differentiation and lymphangiogenesis. The protein is also expressed by stromal cells in peripheral lymphoid tissues and by thymic epithelial cells. Its distribution among lymphatic and specialized stromal cell populations makes PDPN relevant to studies of vascular development, tissue organization and cellular differentiation.
Podoplanin expression has also been investigated extensively in disease and cancer biology. PDPN is found in lymphangiomas, Kaposi sarcomas and subsets of angiosarcoma exhibiting lymphatic differentiation. It is additionally well established in studies of epithelioid mesothelioma and mesothelial differentiation. These broader associations connect the normal lymphatic and stromal biology of PA2.26 antigen with research into pathological tissue remodeling, tumor development and altered cellular phenotypes.
Clone PDPN/8950R is a recombinant rabbit monoclonal antibody generated against a recombinant fragment of human PDPN protein. It has been evaluated by Western blot and immunohistochemistry in human samples, including lung tissue lysate and FFPE tonsil tissue. Recombinant production provides a defined antibody sequence and supports consistent performance across manufacturing lots. NSJ Bioreagents supplies antibodies for lymphatic, vascular and cell biology research. A PA2.26 Antigen Antibody can be used to investigate podoplanin expression, lymphatic endothelial biology, cell-surface glycoproteins and lymphangiogenesis.
For broader research on podoplanin expression and lymphatic endothelial biology, including a protein microarray validated reagent, see our Podoplanin Antibody / Lymphatic Endothelial Cell Marker page.
Optimal dilution of the PA2.26 Antigen Antibody / Podoplanin Glycoprotein Marker should be determined by the researcher.
A recombinant fragment of human PDPN protein was used as the immunogen for the Podoplanin antibody.
Aliquot the Podoplanin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
PA2.26 Antigen antibody, Podoplanin antibody, PDPN antibody, Gp36 antibody, Glycoprotein 36 antibody, T1 Alpha antibody
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