- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
PIWIL1 Antibody / Testicular Germ Cell Marker Antibody (R35993)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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R35993-100UG | 0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide | 100 ug | 475 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Predicted Reactivity | Dog, Mouse, Pig, Rat |
| Format | Antigen affinity purified |
| Host | Goat |
| Clonality | Polyclonal (goat origin) |
| Isotype | Goat Ig |
| Purity | Antigen affinity |
| Gene ID | 9271 |
| Applications | Immunohistochemistry (FFPE) : 4-6ug/ml ELISA (peptide) LOD : 1:64000 |
| Limitations | This PIWIL1 Antibody / Testicular Germ Cell Marker Antibody is available for research use only. |
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PIWIL1 Antibody / Testicular Germ Cell Marker Antibody detects PIWIL1, a member of the PIWI subfamily of Argonaute proteins that plays a critical role in germ cell development, spermatogenesis, stem cell maintenance, and genome integrity. PIWIL1, also known as HIWI in humans, is predominantly expressed in germline tissues and is most strongly associated with the development and maintenance of male germ cells within the testis. Because of its highly restricted expression pattern in normal adult tissues, PIWIL1 is widely utilized as a marker of germline differentiation and reproductive biology.
PIWIL1 functions through interactions with PIWI-interacting RNAs (piRNAs), a specialized class of small non-coding RNAs that regulate gene expression and suppress transposable elements. The PIWIL1-piRNA pathway serves as an essential genome defense mechanism, protecting germ cells from transposon-mediated genomic instability. This pathway contributes to the preservation of genetic integrity during germ cell development and is required for normal reproductive function in many organisms. As a result, PIWIL1 has become a central focus of studies investigating fertility, germline biology, and epigenetic regulation.
Within the testis, PIWIL1 expression is associated with developing germ cells and spermatogenic cell populations. The protein participates in cellular processes that support germ cell survival, differentiation, and maturation, making it a valuable marker for investigations of testicular development and reproductive health. Researchers frequently evaluate PIWIL1 expression to better understand mechanisms controlling germline maintenance, gametogenesis, and the molecular pathways that govern reproductive capacity.
Beyond its established role in normal germline biology, PIWIL1 has attracted significant interest in cancer research. Aberrant PIWIL1 expression has been reported in a variety of human malignancies, where it may contribute to altered cellular proliferation, survival, migration, and stem cell-like properties. Because PIWIL1 belongs to a group of proteins normally enriched in germline tissues but detected in certain tumors, it is frequently studied in the context of cancer-testis antigen biology, tumor progression, and cancer-associated epigenetic regulation.
PIWIL1 Antibody / Testicular Germ Cell Marker Antibody is useful for researchers studying spermatogenesis, germ cell differentiation, reproductive biology, fertility, stem cell regulation, piRNA signaling, epigenetics, and cancer biology. Validation may include applications such as immunohistochemistry, western blotting, immunofluorescence, flow cytometry, and protein expression analysis when supported by experimental data. As a key regulator of germline development and genome protection, PIWIL1 remains an important target for understanding the molecular mechanisms that govern reproductive function, cellular identity, and disease-associated biological pathways.
Explore our Stem Cell Antibodies page for additional markers involved in germline stem cell maintenance, cellular differentiation, and developmental regulation.
Optimal dilution of the PIWIL1 Antibody / Testicular Germ Cell Marker Antibody should be determined by the researcher.
Amino acids SNRKDKYDAIKKY were used as the immunogen for this PIWIL1 antibody.
Aliquot and store the PIWIL1 antibody at -20oC.
PIWIL1 Antibody, Piwi-like Protein 1 Antibody, Piwi Protein Homolog 1 Antibody, HIWI Antibody, Germ Cell Development Protein Antibody, Testicular Germ Cell Marker Antibody
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