- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Phosphohistidine Phosphatase 1 Antibody / Histidine Phosphatase Antibody [clone PHPT1/12054] (V5722)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V5722-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
|
V5722-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
|
|
V5722SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG |
| Clone Name | PHPT1/12054 |
| Purity | Protein A/G affinity |
| UniProt | Q9NRX4 |
| Localization | Cytoplasm |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This Phosphohistidine Phosphatase 1 Antibody / Histidine Phosphatase Antibody is available for research use only. |
|
Review this product on BioCompare and get a $20 Amazon gift card
|
Related Products
|
Phosphohistidine Phosphatase 1 Antibody / Histidine Phosphatase Antibody targets PHPT1, a small cytoplasmic phosphatase involved in the regulation of protein histidine phosphorylation. PHPT1, also known as protein histidine phosphatase (PHP) and 14 kDa phosphohistidine phosphatase, is a highly conserved protein of approximately 125 amino acids. Histidine phosphorylation is a reversible post-translational modification that remains less characterized than phosphorylation of serine, threonine and tyrosine. PHPT1 was the first eukaryotic protein histidine phosphatase identified and has become an important protein for investigating this noncanonical phosphorylation pathway.
PHPT1 catalyzes the removal of phosphate from phosphohistidine-containing protein substrates and helps regulate the balance of histidine phosphorylation. An established PHPT1 substrate is ATP-citrate lyase (ACLY), an important metabolic enzyme in which histidine phosphorylation participates in catalytic activity. PHPT1 has also been associated with signaling involving heterotrimeric G proteins and regulation of the KCa3.1 potassium channel, connecting this histidine phosphatase with cellular signaling, ion-channel activity and metabolic regulation.
Research into PHPT1 has expanded alongside growing interest in mammalian histidine phosphorylation. PHPT1 activity has been investigated in pancreatic beta cells, where altered expression can affect ATP-citrate lyase activity and fuel-stimulated insulin secretion. Mammalian phosphohistidine signaling also involves proteins such as the histidine kinases NME1 and NME2 and the phosphatase LHPP. Studying the expression and distribution of these regulatory proteins can help define the roles of reversible histidine phosphorylation in normal physiology and disease.
This mouse monoclonal antibody was generated against recombinant human PHPT1 and is validated for immunohistochemical detection in human FFPE tissue. NSJ Bioreagents provides this Phosphohistidine Phosphatase 1 Antibody for research into PHPT1 expression, protein phosphorylation, cell signaling and metabolic regulation. A Histidine Phosphatase Antibody can support studies examining PHPT1 distribution and the emerging biology of reversible histidine phosphorylation.
Because PHPT1 regulates a reversible protein phosphorylation pathway, researchers studying this target may also find our Phospho Antibody - Phosphorylation Specific Antibodies page useful for broader phosphorylation-focused research.
Optimal dilution of the Phosphohistidine Phosphatase 1 Antibody / Histidine Phosphatase Antibody should be determined by the researcher.
A recombinant human 14 kDa phosphohistidine phosphatase protein was used as the immunogen for the Phosphohistidine phosphatase 1 antibody.
Aliquot the Phosphohistidine phosphatase 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
PHPT1 antibody, phosphohistidine phosphatase 1 antibody, histidine phosphatase antibody, 14 kDa phosphohistidine phosphatase antibody, protein histidine phosphatase antibody, PHP antibody
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.
Powered by Bioz
