- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
PTEN (pT382) Antibody / Phospho-PTEN Thr382 Antibody (F48739)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
F48739-0.4ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.4 ml | 439 | |
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F48739-0.08ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.08 ml | 205 |
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| Availability | 1-3 business days |
| Species Reactivity | Human |
| Predicted Reactivity | Mouse, Xenopus |
| Format | Antigen affinity purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Purity | Antigen affinity |
| UniProt | P60484 |
| Applications | Dot Blot : 1:500 |
| Limitations | This PTEN (pT382) Antibody / Phospho-PTEN Thr382 Antibody is available for research use only. |
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PTEN (pT382) Antibody / Phospho-PTEN Thr382 Antibody recognizes PTEN when phosphorylated at threonine 382. PTEN, or phosphatase and tensin homolog, is a major tumor suppressor that negatively regulates phosphoinositide 3-kinase (PI3K)/AKT signaling. PTEN dephosphorylates phosphatidylinositol (3,4,5)-trisphosphate (PIP3), opposing PI3K activity and limiting downstream signaling involved in cellular proliferation, survival, growth and metabolism.
PTEN is regulated by multiple post-translational modifications, including phosphorylation of residues within its C-terminal tail. Threonine 382 lies within a regulatory phosphorylation cluster that includes Ser380, Thr382, Thr383 and Ser385. Modification of residues within this region can influence PTEN conformation, protein stability, membrane association and phosphatase activity, providing an important mechanism for controlling PTEN function independently of changes in total protein abundance.
Phosphorylation of the PTEN C-terminal tail is associated with conformational regulation of the protein. Increased phosphorylation within this region can favor a more closed conformation that enhances PTEN stability while limiting its association with the plasma membrane and accessibility to membrane-associated substrates. Dephosphorylation can promote a more open state with increased membrane interaction and catalytic activity, although it may also affect protein stability. A PTEN (pT382) Antibody can help distinguish the Thr382-phosphorylated population of PTEN from total PTEN in studies examining these regulatory mechanisms.
Phosphorylation-dependent PTEN regulation is particularly relevant to cancer and cell signaling research. Loss of PTEN activity through mutation, deletion, reduced expression or altered regulation can increase PI3K/AKT pathway signaling and contribute to abnormal cell survival and proliferation. Analysis of Thr382 phosphorylation can complement measurements of total PTEN expression by providing information about a specific regulatory modification that may influence PTEN behavior and signaling activity.
Researchers investigating PTEN phosphorylation and related post-translational signaling mechanisms can explore our Phospho Antibody - Phosphorylation Specific Antibodies page for additional reagents targeting phosphorylation-dependent events in cell signaling, growth regulation and disease biology.
NSJ Bioreagents offers PTEN (pT382) Antibody for research into phosphorylation-dependent regulation of PTEN. A Phospho-PTEN Thr382 Antibody can support studies of PTEN regulation, PI3K/AKT signaling, tumor suppressor biology and mechanisms involving site-specific phosphorylation of the PTEN C-terminal regulatory region.
For broader research into PTEN expression and tumor suppressor function, explore our PTEN Antibody page for additional reagents targeting phosphatase and tensin homolog.
Titration of the PTEN (pT382) Antibody / Phospho-PTEN Thr382 Antibody may be required due to differences in protocols and secondary/substrate sensitivity.
This PTEN (pT382) Antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pT382 of human PTEN.
Aliquot the PTEN (pT382) Antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
PTEN (pT382) antibody, Phospho-PTEN Thr382 antibody, PTEN phospho-Thr382 antibody, PTEN pThr382 antibody, PTEN Thr382 antibody, Phosphatase and Tensin Homolog antibody
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