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- Email: info@nsjbio.com
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This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.
Titration of the phospho-c-Kit antibody may be required due to differences in protocols and secondary/substrate sensitivity.
This phospho-c-Kit antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pY578 of human c-Kit.
Aliquot the phospho-c-Kit antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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