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- Tel: 858.663.9055
- Email: info@nsjbio.com
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BAD promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2. Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
Titration of the phospho-Bad antibody may be required due to differences in protocols and secondary/substrate sensitivity.
This phospho-Bad antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS96 of mouse Bad.
Aliquot the phospho-Bad antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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