- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
PD-L1 Antibody PE Conjugate [clone PDL1/2746] (V3955PE)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V3955PE-100T | 500 ul at 0.1 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 Tests | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | PE Conjugate |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2b, kappa |
| Clone Name | PDL1/2746 |
| Purity | Protein G affinity chromatography |
| UniProt | Q9NZQ7 |
| Localization | Cell surface, cytoplasmic |
| Applications | Flow Cytometry : 1-2ug/million cells in 0.1ml Immunofluorescence : 1-2ug/ml |
| Limitations | This PD-L1 antibody is available for research use only. |
|
Review this product on BioCompare and get a $20 Amazon gift card
|
Related Products
|
Programmed death-ligand 1 (PD-L1), encoded by the CD274 gene, is a type I transmembrane immune checkpoint ligand that plays an essential role in regulating T cell activation and maintaining immune tolerance. PD-L1 Antibody PE Conjugate (clone PDL1/2746) recognizes this immunoregulatory surface protein, which is widely referred to in the literature as PD-L1, CD274, or B7-H1. PD-L1 belongs to the B7 family of immune regulatory molecules and functions primarily through interaction with the inhibitory receptor PD-1 expressed on activated T lymphocytes. This receptor-ligand interaction suppresses T cell proliferation and cytokine production, helping control immune responses and prevent excessive immune activation.
Under normal physiological conditions, PD-L1 expression is detected on antigen-presenting cells such as dendritic cells and macrophages, as well as on various epithelial and endothelial cell types. Expression can be induced by inflammatory cytokines, particularly interferon-gamma, which activates transcriptional pathways that increase PD-L1 levels during immune responses. Through this regulatory mechanism, PD-L1 helps modulate immune activation and maintain immune homeostasis in tissues exposed to inflammatory stimuli.
The CD274 gene is located on chromosome 9p24.1 and encodes a glycosylated cell surface protein containing extracellular immunoglobulin-like domains typical of B7 family members. PD-L1 is primarily localized to the plasma membrane where it functions as a ligand for PD-1 on T cells. Because PD-L1 regulates immune checkpoint signaling, it has become a major focus of immunology and oncology research. Many tumors increase PD-L1 expression on the surface of malignant epithelial cells or tumor-associated immune cells, allowing them to suppress anti-tumor immune responses and evade immune surveillance. As a result, CD274 antibody reagents are widely used in studies investigating tumor immune evasion, immune checkpoint pathways, and immune microenvironment interactions.
Several strong literature synonyms are associated with this checkpoint ligand, including PD-L1, Programmed death-ligand 1, B7-H1, and PDCD1 ligand 1. These established names ensure consistent identification of the CD274 immune checkpoint protein across immunology and cancer biology research. Because PD-L1 is expressed on the cell surface, fluorescent conjugated antibodies such as PE-labeled reagents enable direct detection of PD-L1-positive cell populations in immunophenotyping experiments. The PE-conjugated mouse monoclonal PD-L1 antibody clone PDL1/2746 is suitable for studies examining immune checkpoint expression, tumor immune biology, and cellular immune responses, and is available from NSJ Bioreagents.
Optimal dilution of the PD-L1 antibody should be determined by the researcher.
A portion of amino acids 39-191 from the human protein was used as the immunogen for this PD-L1 antibody.
Store the PD-L1 antibody at 2-8oC, protected from light.
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.
Powered by Bioz
