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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Ecto-nucleotide pyrophosphatase/phosphodiesterase-I enzymes (E-NPP), a group of type II transmembrane proteins, cleave phosphodiester and phosphosulfate bonds in deoxynucleotides, NAD, and nucleotide sugars. There exist three closely related proteins in mammalian species: E-NPP1 (PC-1), E-NPP2 (PDNP2), and E-NPP-3 (PDNP3) which is also known as CD203c, each expressed in different cells or at different locations in the same cells. Basophils, a type of major proinflammatory effector cells involved in diverse pathologic reactions, exhibit CD203c expression. For instance, CD203c expression increases in response to a variety of allergens, including cat dander, latex, and bee and wasp venom. However, these allergies are not the only condition associated with CD203c upregulation; CD203c upregulation may also serve as a tumor marker for colon carcinoma.
Optimal dilution of the PD-Ibeta antibody should be determined by the researcher.
A portion of amino acids 300-600 from human ENPP3 protein was used as the immunogen for the PD-Ibeta antibody.
Aliquot the PD-Ibeta antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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