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Home >> Antibodies >> PD-Ibeta Antibody / PDNP3 / ENPP3 / CD203c

PD-Ibeta Antibody / PDNP3 / ENPP3 / CD203c [clone ENPP3/9891] (V5773)

  Catalog No Formulation Size Price (USD)  
Image V5773-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 539
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V5773-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 249
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V5773SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 539
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IHC staining of FFPE human kidney tissue with PD-Ibeta antibody (clone ENPP3/9891). Inset: PBS used in place of primary Ab (secondary Ab negative control). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
SDS-PAGE analysis of purified, BSA-free PD-Ibeta antibody (clone ENPP3/9891) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG, kappa
Clone Name ENPP3/9891
Purity Protein A/G affinity
UniProt O14638
Localization Apical cell membrane, Cell membrane, Secreted
Applications Immunohistochemistry (FFPE) : 1-2ug/ml
Limitations This PD-Ibeta antibody is available for research use only.
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Description

Ecto-nucleotide pyrophosphatase/phosphodiesterase-I enzymes (E-NPP), a group of type II transmembrane proteins, cleave phosphodiester and phosphosulfate bonds in deoxynucleotides, NAD, and nucleotide sugars. There exist three closely related proteins in mammalian species: E-NPP1 (PC-1), E-NPP2 (PDNP2), and E-NPP-3 (PDNP3) which is also known as CD203c, each expressed in different cells or at different locations in the same cells. Basophils, a type of major proinflammatory effector cells involved in diverse pathologic reactions, exhibit CD203c expression. For instance, CD203c expression increases in response to a variety of allergens, including cat dander, latex, and bee and wasp venom. However, these allergies are not the only condition associated with CD203c upregulation; CD203c upregulation may also serve as a tumor marker for colon carcinoma.

Application Notes

Optimal dilution of the PD-Ibeta antibody should be determined by the researcher.

Immunogen

A portion of amino acids 300-600 from human ENPP3 protein was used as the immunogen for the PD-Ibeta antibody.

Storage

Aliquot the PD-Ibeta antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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