- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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PAX2 Antibody / Paired Box 2 Antibody recognizes PAX2, a nuclear transcription factor belonging to the paired box family of developmental regulatory proteins. PAX2 contains a conserved paired DNA-binding domain that enables sequence-specific regulation of genes involved in embryonic development, cellular differentiation, and organogenesis. Expression is particularly important during development of the kidney and urogenital system, as well as selected structures of the central nervous system, eye, and ear. PAX2 expression is tightly regulated spatially and temporally, reflecting its role in establishing and maintaining developmental cell lineages.
PAX2 has a particularly important role in renal development. It participates in specification and differentiation of the intermediate mesoderm and subsequent formation of the nephric lineage, ureteric bud, and developing kidney. PAX2 expression is prominent in embryonic renal tissues but becomes substantially restricted in most mature renal structures. Genetic alterations affecting PAX2 can disrupt normal development and are associated with renal and ocular abnormalities. A PAX2 Antibody can therefore support studies of kidney organogenesis, renal cell differentiation, developmental transcriptional regulation, and urogenital biology.
Re-expression or persistent expression of PAX2 has also been investigated in cancer. PAX2 is associated with several renal and Müllerian-derived tumors and is frequently studied in the characterization of neoplasms involving the kidney and female reproductive tract. Its expression in selected tumor types has made PAX2 useful in research examining tumor differentiation, developmental transcription programs, and the relationship between embryonic regulatory pathways and cancer. A Paired Box 2 Antibody can support investigations of PAX2 expression in renal, ovarian, endometrial, and other tumors in which this transcription factor may contribute to lineage-associated biology.
Clone PAX2/1105 is a mouse monoclonal antibody directed against PAX2 and has been evaluated using a human protein microarray to assess target recognition and potential cross-reactivity across a broad panel of human proteins. Protein microarray validation provides an additional layer of specificity assessment that complements application-specific testing. NSJ Bioreagents offers PAX2/1105 for research involving developmental biology, transcriptional regulation, renal biology, and cancer. This PAX2 Antibody is a Protein Microarray Validated monoclonal reagent for investigating Paired Box 2 expression and PAX2-associated developmental and disease biology.
Explore our Transcription Factor Antibodies page to find additional antibodies for studying transcriptional regulation, gene expression, cellular differentiation, and developmental signaling.
Optimal dilution of the PAX2 Antibody / Paired Box 2 Antibody should be determined by the researcher.
A portion of amino acids 223-354 was used as the immunogen for the PAX2 antibody.
Aliquot the PAX2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
PAX2 antibody, Paired Box 2 antibody, PAX-2 antibody, Paired Box Gene 2 antibody
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