- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Orthodenticle Homolog 2 Antibody recognizes OTX2, a homeobox-containing transcription factor that is indispensable for vertebrate embryonic development and central nervous system patterning. OTX2 regulates gene expression programs that direct formation of the forebrain, midbrain, retina, retinal pigment epithelium, pineal gland, inner ear, and pituitary gland. Through sequence-specific DNA binding, OTX2 controls cellular differentiation, tissue specification, and organ development, making it one of the key developmental transcription factors required during early embryogenesis.
Orthodenticle homolog 2 remains biologically important after development, where it supports maintenance of retinal cells and specialized neuronal populations. In the visual system, OTX2 is essential for photoreceptor differentiation, retinal pigment epithelial cell function, and long-term retinal homeostasis. It also contributes to neuronal maturation and cortical plasticity through intercellular transfer to specific interneuron populations. An OTX2 Antibody is therefore widely used to investigate neural development, retinal biology, and stem cell differentiation.
Aberrant expression of orthodenticle homolog 2 has been associated with congenital developmental abnormalities and several human cancers. Increased OTX2 expression has been reported in medulloblastoma, retinoblastoma, pineoblastoma, and additional malignancies where it promotes cellular proliferation, lineage maintenance, and tumor progression. Consequently, researchers frequently examine orthodenticle homolog 2 together with other developmental transcription factors to better understand embryogenesis, neurobiology, and oncogenic signaling pathways.
An Orthodenticle Homolog 2 Antibody is a valuable research tool for investigating OTX2 expression, transcriptional regulation, neural development, retinal biology, stem cell differentiation, and cancer biology.
For additional information about this developmental transcription factor, see our OTX2 Antibody / Orthodenticle Homeobox 2 Antibody page.
Titration of the Orthodenticle Homolog 2 Antibody may be required due to differences in protocols and secondary/substrate sensitivity.
This OTX2 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 201-226 amino acids from the C-terminal region of human OTX2.
Aliquot the OTX2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Orthodenticle Homolog 2 antibody, OTX2 antibody, Orthodenticle Homeobox 2 antibody, Homeobox Protein OTX2 antibody
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