- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
SF-1 Antibody / Steroidogenic Transcription Factor Antibody [clone NR5A1/3397] (V8731)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V8731-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
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V8731-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V8731SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2b, kappa |
| Clone Name | NR5A1/3397 |
| Purity | Protein G affinity chromatography |
| UniProt | Q13285 |
| Localization | Nuclear |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT |
| Limitations | This SF-1 Antibody / Steroidogenic Transcription Factor Antibody is available for research use only. |
|
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Steroidogenic factor 1 (NR5A1), commonly known as SF-1, is an orphan nuclear receptor transcription factor that functions as a master regulator of steroidogenic tissue development, endocrine differentiation, and hormone-associated transcriptional regulation. SF-1 plays critical roles in adrenal gland formation, gonadal development, reproductive tissue specification, and transcriptional control of genes involved in steroid hormone biosynthesis. SF-1 Antibody is useful for investigations involving endocrine differentiation pathways, steroidogenic tissue biology, reproductive development, and nuclear receptor-associated transcriptional regulation.
SF-1 antibody, also referred to as NR5A1 antibody, Steroidogenic factor 1 antibody, and Ad4BP antibody in the literature, recognizes a nuclear receptor encoded on chromosome 9q33.3. NR5A1 localizes predominantly to the nucleus, where it regulates expression of genes involved in steroidogenesis, endocrine tissue specification, cholesterol metabolism, gonadal differentiation, and reproductive signaling pathways. Expression of SF-1 is strongly associated with adrenal cortical cells, gonadal stromal populations, steroid-producing tissues, and subsets of endocrine-associated neoplasms.
SF-1 Antibody / Steroidogenic Transcription Factor Antibody (clone NR5A1/3397) is uniquely positioned for studies involving endocrine lineage specification and steroidogenic tissue-associated transcriptional regulation. This mouse monoclonal antibody demonstrates strong immunohistochemical detection of SF-1 together with HuProt microarray specificity validation against more than 19,000 full-length human proteins. The broad validation profile supports use of clone NR5A1/3397 in investigations involving adrenal biology, gonadal differentiation, steroid hormone-associated signaling pathways, and endocrine tumor characterization.
Analysis of HuProt(TM) microarrays containing more than 19,000 individually purified full-length human proteins demonstrated highly selective recognition of NR5A1 by clone NR5A1/3397. In HuProt(TM) analysis, the Z-score represents the strength of antibody binding signal relative to the overall array mean, while the S-score reflects target specificity relative to the next highest ranked protein signal. Elevated S-score separation supports preferential target recognition and reduced off-target binding across the tested human proteome. This specificity validation approach is valuable for tissue-based studies involving nuclear transcription factors and heterogeneous endocrine cellular environments.
SF-1 functions as a central transcriptional regulator of genes involved in steroid hormone synthesis including CYP11A1, CYP17A1, STAR, and additional steroidogenic enzymes required for adrenal and gonadal endocrine activity. Altered NR5A1 expression has been associated with disorders of sex development, adrenal dysfunction, gonadal abnormalities, endocrine tumor progression, reproductive signaling alterations, and steroidogenic pathway dysregulation. Because SF-1 is closely linked to steroid-producing cellular populations, it has become an important marker in studies involving endocrine lineage identity and reproductive tissue-associated neoplasia.
This SF-1 Antibody supports research involving steroidogenic transcriptional regulation, endocrine differentiation pathways, adrenal cortical biology, gonadal development, reproductive signaling, nuclear receptor-associated transcriptional control, and endocrine tumor-associated cellular regulation. Clone NR5A1/3397 may be incorporated into immunohistochemistry and tissue-based investigations examining steroidogenic lineage specification and endocrine-associated transcriptional networks.
Explore additional endocrine differentiation and steroidogenic pathway markers on our Cancer Antibodies landing page, including antibodies targeting nuclear receptor signaling and endocrine-associated tumor biology.
Optimal dilution of the SF-1 Antibody / Steroidogenic Transcription Factor Antibody should be determined by the researcher.
A portion of amino acids 220-461 from human Steroidogenic factor 1 was used as the immunogen for the NR5A1 / SF-1 antibody.
Store the NR5A1 / SF-1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
NR5A1 antibody, SF-1 antibody, Steroidogenic factor 1 antibody, Ad4BP antibody, Nuclear receptor subfamily 5 group A member 1 antibody
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