- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
NECAB1 Antibody / N-terminal EF-hand calcium binding protein 1 (RQ8232)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RQ8232 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 439 |
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse, Rat |
| Format | Antigen affinity purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity purified |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| UniProt | Q8N987 |
| Localization | Nuclear, cytoplasmic |
| Applications | Western Blot : 0.5-1ug/ml Immunohistochemistry (FFPE) : 2-5ug/ml Immunofluorescence : 5ug/ml Direct ELISA : 0.1-0.5ug/ml |
| Limitations | This NECAB1 antibody is available for research use only. |
|
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NECAB1 antibody targets N-terminal EF-hand calcium binding protein 1 (NECAB1), a neuronal calcium-binding protein that contributes to calcium-dependent signaling and synaptic function. NECAB1 contains EF-hand motifs that enable calcium binding and conformational changes in response to intracellular calcium fluctuations. The protein localizes predominantly to the cytoplasm and neuronal processes, with enrichment in specific neuronal populations, consistent with a role in regulating calcium-sensitive signaling pathways and neuronal excitability.
Functionally, NECAB1 participates in modulating calcium dynamics that influence neurotransmission and synaptic activity. Calcium-binding proteins such as NECAB1 act as buffers or sensors that translate calcium transients into downstream biochemical responses, thereby shaping neuronal signaling precision. NECAB1 expression is enriched in the nervous system, including cortical and subcortical regions, suggesting involvement in region-specific neuronal function. An NECAB1 antibody supports studies examining calcium-regulated processes in neurons and neural circuits.
NECAB1 has been associated with synaptic organization and neuronal differentiation, where calcium signaling plays a critical instructive role. Changes in NECAB1 expression or localization may influence synaptic strength and plasticity by altering calcium-dependent pathways. These properties make NECAB1 a useful marker for investigating neuronal calcium signaling and its contribution to network activity and development. An NECAB1 antibody enables analysis of NECAB1 distribution and relative abundance in neural tissues and experimental models.
From a biological and disease-relevance perspective, neuronal calcium-binding proteins are widely studied for their roles in neurodevelopmental processes and neurological disorders where calcium homeostasis is disrupted. Although NECAB1 is less extensively characterized than some calcium sensors, its conserved EF-hand domains and neuronal enrichment suggest functional relevance in maintaining calcium signaling balance. Studying NECAB1 expression can provide insight into calcium-dependent regulatory mechanisms in the nervous system.
At the molecular level, NECAB1 is encoded by the NECAB1 gene and produces a protein of approximately 290 amino acids. The N-terminal EF-hand motifs mediate calcium binding, while additional regions support protein-protein interactions and cellular localization. Regulation of NECAB1 expression is linked to neuronal identity and developmental state. An NECAB1 antibody supports research applications focused on neuronal calcium signaling, synaptic biology, and neurobiological regulation, with NSJ Bioreagents providing reagents intended for research use.
Optimal dilution of the NECAB1 antibody should be determined by the researcher.
E. coli-derived recombinant human protein (amino acids E16-E296) was used as the immunogen for the NECAB1 antibody.
After reconstitution, the NECAB1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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