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Home >> Antibodies >> Mutated in Colorectal Cancers Antibody / MCC

Mutated in Colorectal Cancers Antibody / MCC (RQ6655)

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  Catalog No Formulation Size Price (USD)  
Image RQ6655 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Flow cytometry testing of human HeLa cells with Mutated in Colorectal Cancers antibody at 1ug/million cells (blocked with goat sera); Red=cells alone, Green=isotype control, Blue= Mutated in Colorectal Cancers antibody.
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Flow cytometry testing of human HeLa cells with Mutated in Colorectal Cancers antibody at 1ug/million cells (blocked with goat sera); Red=cells alone, Green=isotype control, Blue= Mutated in Colorectal Cancers antibody.
Western blot testing of 1) human U-87 MG, 2) human HEK293, 3) human HeLa, 4) rat brain, 5) rat lung, 6) mouse brain and 7) mouse lung tissue lysate with Mutated in Colorectal Cancers antibody. Predicted molecular weight ~91 kDa.
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity purified
Buffer Lyophilized from 1X PBS with 2% Trehalose
UniProt P23508
Applications Western blot : 1-2ug/ml
Flow cytometry : 1-3ug/million cells
Direct ELISA : 0.1-0.5ug/ml
Limitations This Mutated in Colorectal Cancers antibody is available for research use only.
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Description

MUTATED IN COLORECTAL CANCERS (MCC) is a tumor suppressor gene. It is mapped to 5q22.2. This gene suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. MCC also Inhibits DNA binding of b-catenin/TCF/LEF transcription factors, and it is Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation. What's more, MCC can interact with SCRIB (via phosphorylated PDZ-binding motif), EZR, SNX27, SLC9A3R1 and SLC9A3R2.

Application Notes

Optimal dilution of the Mutated in Colorectal Cancers antibody should be determined by the researcher.

Immunogen

Recombinant human protein (amino acids M1-E234) was used as the immunogen for the Mutated in Colorectal Cancers antibody.

Storage

After reconstitution, the Mutated in Colorectal Cancers antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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