- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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MTAP antibody is a specific reagent for detecting methylthioadenosine phosphorylase, an enzyme encoded by the MTAP gene. MTAP is involved in the methionine salvage pathway, where it catalyzes the cleavage of methylthioadenosine into adenine and 5-methylthioribose-1-phosphate. This process recycles methionine and supports polyamine metabolism. Because of its essential role in cellular metabolism and its frequent deletion in cancer, MTAP is a subject of significant biomedical interest.
MTAP expression is normally found in a wide range of tissues, reflecting its fundamental metabolic role. However, loss of MTAP is common in tumors, especially those with deletions at chromosome 9p21, where MTAP lies near the CDKN2A gene. This co-deletion occurs in multiple cancers, including gliomas, pancreatic carcinomas, and mesotheliomas. As a result, MTAP serves as both a tumor suppressor candidate and a biomarker for cancer classification.
The MTAP antibody clone MTAP/1813 ensures reproducible and accurate detection of this enzyme. Recombinant production guarantees consistency across batches, reducing variability in experimental outcomes. Clone MTAP/1813 has been used in studies of tumor biology, metabolic regulation, and translational cancer research. Peer-reviewed publications highlight MTAP detection in investigations of metabolic vulnerabilities that may be exploited for therapy, demonstrating the antibodyâs research significance.
Research with clone MTAP/1813 has clarified how MTAP deletion alters methionine metabolism and creates synthetic lethal interactions with PRMT5 and MAT2A pathways. These findings have made MTAP deficiency an emerging therapeutic target, where drugs can selectively exploit metabolic weaknesses in MTAP-deficient cancers. Detecting MTAP expression is therefore important in both experimental and clinical settings.
NSJ Bioreagents supplies this MTAP antibody to support research in cancer biology, metabolism, and therapeutic discovery. MTAP is also referred to as methylthioadenosine phosphorylase antibody, adenine salvage enzyme antibody, 5-methylthioribose phosphorylase antibody, and tumor suppressor candidate antibody.
Optimal dilution of the MTAP antibody should be determined by the researcher.
A portion of amino acids 97-196 from the human protein was used as the immunogen for the MTAP antibody.
Store the MTAP antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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