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- Tel: 858.663.9055
- Email: info@nsjbio.com
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The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Titration of the MCM7 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 290-318 from the human protein was used as the immunogen for this MCM7 antibody.
Aliquot the MCM7 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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