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Home >> Antibodies >> Lats2 Antibody

Lats2 Antibody (F47336)

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  Catalog No Formulation Size Price (USD)  
Image F47336-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 399
Image
F47336-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 185
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Lats2 antibody western blot analysis in mouse testis tissue lysate.
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Lats2 antibody western blot analysis in mouse testis tissue lysate.
IHC staining of FFPE mouse testis with Lats2 antibody. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
Availability 1-3 business days
Species Reactivity Mouse
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt Q7TSJ6
Localization Nuclear
Applications Western blot : 1:1000
Immunohistochemistry : 1:100
Limitations This Lats2 antibody is available for research use only.
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  • Applications : WB, IHC, ELISA
    Reactivity : Human, Mouse

Description

Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor (By similarity).

Application Notes

Titration of the Lats2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 1000-1027 from the mouse protein was used as the immunogen for this Lats2 antibody.

Storage

Aliquot the Lats2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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