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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Kininogen Antibody / KNG1 Polyclonal Antibody (R31691)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
R31691 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 449 |
|
| Species Reactivity | Human |
| Format | Antigen affinity purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity |
| Buffer | Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide |
| Gene ID | 3827 |
| Applications | Western Blot : 0.5-1ug/ml |
| Limitations | This Kininogen Antibody / KNG1 Polyclonal Antibody is available for research use only. |
|
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Kininogen Antibody recognizes kininogen 1 (KNG1), a circulating plasma glycoprotein involved in blood coagulation, inflammatory signaling, and vascular homeostasis. The KNG1 gene produces two major alternatively spliced proteins, high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). These isoforms share an extensive N-terminal region but differ in their C-terminal sequences and functional interactions. Kininogens are synthesized primarily by hepatocytes and secreted into the bloodstream, where they participate in proteolytic pathways that regulate vascular responses and inflammatory mediator production.
High molecular weight kininogen is an essential cofactor in the plasma contact activation system, supporting the assembly of prekallikrein and coagulation factor XI on negatively charged surfaces. During contact activation, plasma kallikrein cleaves HMWK to release bradykinin, a nine-amino-acid peptide that promotes vasodilation, increases vascular permeability, and contributes to inflammatory responses. Low molecular weight kininogen can also serve as a precursor for kinin generation but lacks the specialized contact system binding regions found in HMWK. Both isoforms contain cystatin-like domains associated with protease regulation.
KNG1 is extensively studied in disorders involving abnormal kallikrein-kinin signaling, including hereditary angioedema, vascular inflammation, and thromboinflammatory conditions. Excessive bradykinin generation contributes to the episodic tissue swelling characteristic of certain forms of hereditary angioedema. Experimental studies have also investigated kininogen function in thrombosis, ischemia-reperfusion injury, and inflammatory responses involving endothelial cells. The relationship between contact activation and innate immunity has made KNG1 an important subject in research examining interactions between coagulation and inflammation.
Beyond vascular disorders, altered kininogen abundance and proteolytic fragments have been investigated as potential biomarkers in cancer and inflammatory disease. Because KNG1 is predominantly a secreted plasma protein, its presence in tissues may reflect circulating protein, local synthesis, or extracellular deposition. Glycosylation and proteolytic processing can influence the apparent molecular weight of detected kininogen species. NSJ Bioreagents offers a rabbit polyclonal antibody raised against recombinant human KNG1 amino acids 19-210, a region shared by the major kininogen isoforms and distinct from the mature bradykinin peptide. A Kininogen Antibody provides a useful tool for investigating KNG1 expression, protein processing, and the molecular pathways connecting coagulation, inflammation, and vascular biology.
For additional research into kininogen expression, bradykinin generation, and vascular inflammatory pathways, explore our KNG1 Antibody page.
The stated application concentrations are suggested starting amounts. Titration of the Kininogen Antibody / KNG1 Polyclonal Antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Human partial recombinant protein (AA 19-210) was used as the immunogen for this Kininogen antibody.
After reconstitution, the Kininogen antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Kininogen 1 antibody, KNG1 antibody, Plasma Kininogen antibody, High Molecular Weight Kininogen antibody, Low Molecular Weight Kininogen antibody, HMWK antibody, LMWK antibody, Bradykinin Precursor antibody
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