- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Interleukin 2 Antibody recognizes IL-2, an immunoregulatory cytokine encoded by the IL2 gene. IL-2 is produced predominantly by activated T cells and plays an important role in coordinating lymphocyte proliferation, differentiation, survival, and immune homeostasis. Originally characterized for its ability to promote T-cell growth, IL-2 is now recognized as a cytokine with both immune-stimulatory and immune-regulatory functions.
IL-2 signals through a receptor system composed of IL2RA (CD25), IL2RB (CD122), and the common gamma chain IL2RG (CD132). The high-affinity IL-2 receptor contains all three subunits, whereas IL2RB and IL2RG form an intermediate-affinity receptor. Receptor engagement activates intracellular pathways including JAK1, JAK3, STAT5, PI3K-AKT, and MAPKs, producing cellular responses that depend on receptor expression and the physiological state of the responding cell.
IL-2 influences conventional T cells, regulatory T cells, and natural killer cells. It can support proliferation and effector functions in activated lymphocytes while also contributing to the development, maintenance, and suppressive activity of regulatory T cells. These complementary functions make IL-2 important in studies of immune tolerance, host defense, autoimmunity, inflammation, and tumor immunity.
This antigen-affinity-purified rabbit polyclonal antibody was generated against amino acids 21-153 of human IL-2. As an IL2 Cytokine Antibody, it provides a reagent for investigating a signaling molecule central to communication and regulation among immune cells. NSJ Bioreagents supplies this antibody for research use only.
An Interleukin 2 Antibody can be used to investigate IL-2 expression and molecular mechanisms connecting cytokine signaling, lymphocyte activation, immune regulation, and adaptive immune responses.
For a monoclonal clone with IHC and protein microarray specificity validation, see our Interleukin-2 Antibody IL2/4983 / IL-2 Antibody page.
Optimal dilution of the Interleukin 2 Antibody / IL2 Cytokine Antibody should be determined by the researcher.
Amino acids A21-T153 from the human protein were used as the immunogen for the Interleukin 2 Antibody.
After reconstitution, the Interleukin 2 Antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
IL2 antibody, IL-2 antibody, interleukin 2 antibody, interleukin-2 antibody, T cell growth factor antibody, T-cell growth factor antibody, TCGF antibody, lymphokine antibody
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