- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CD25 Antibody / IL2RA [clone IL2RA/9378R] (V5920)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V5920-100UG | 0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide | 100 ug | 559 | |
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V5920-20UG | 0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide | 20 ug | 259 | |
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V5920SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | IL2RA/9378R |
| UniProt | P01589 |
| Localization | Cell membrane, Cytoplasm |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This CD25/IL2RA antibody is available for research use only. |
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CD25 antibody targets Interleukin-2 receptor subunit alpha (IL2RA), a type I transmembrane cytokine receptor component that forms the high-affinity interleukin-2 receptor complex together with IL2RB and IL2RG. IL2RA, also widely known as CD25, is primarily localized to the cell membrane and plays a central role in regulating immune activation and cytokine responsiveness. Expression of CD25 is minimal on resting lymphocytes but is rapidly induced following antigen stimulation, making an IL2RA antibody a widely used tool for studying immune activation dynamics.
Interleukin-2 receptor subunit alpha belongs to the type I cytokine receptor family and lacks intrinsic kinase activity, instead functioning by increasing the affinity of the receptor complex for interleukin-2 and enabling downstream signaling through JAK-STAT pathways. CD25 is constitutively expressed at high levels on regulatory T cells, where it supports immune tolerance and suppression of excessive immune responses. Detection with a CD25 / IL2RA antibody is therefore commonly used to identify regulatory T cell populations and to investigate immune homeostasis mechanisms.
Beyond T lymphocytes, IL2RA expression has been observed in activated B cells and certain antigen-presenting cell populations, reflecting broader roles in immune regulation. Altered expression of Interleukin-2 receptor subunit alpha has been linked to autoimmune disease, inflammatory disorders, and hematologic malignancies, highlighting its relevance in immunopathology research. A CD25 antibody enables analysis of IL2RA expression patterns in immune tissues and disease-associated microenvironments.
Structurally, Interleukin-2 receptor subunit alpha is a glycoprotein with an extracellular cytokine-binding domain, a single transmembrane region, and a short cytoplasmic tail. Because IL2RA expression reflects immune activation state rather than antigen specificity, antibody-based detection of CD25 provides a direct readout of cytokine receptor engagement and immune cell activation. Clone IL2RA/9378R is designed to recognize Interleukin-2 receptor subunit alpha and supports detection of IL2RA expression in research applications. NSJ Bioreagents offers this CD25 antibody for studies of immune regulation, cytokine signaling, and T cell biology.
Optimal dilution of the CD25/IL2RA antibody should be determined by the researcher.
A recombinant fragment (around amino acids 1-250) of human IL2RA protein (exact sequence is proprietary) was used as the immunogen for the CD25/IL2RA antibody.
CD25/IL2RA antibody with sodium azide - store at 2 to 8oC; antibody without sodium azide - store at -20 to -80oC.
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