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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
IFN gamma Antibody IFNG/466 / Immune Interferon Antibody [clone IFNG/466] (V3193)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V3193-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
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V3193-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
|
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V3193SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2b, kappa |
| Clone Name | IFNG/466 |
| Purity | Protein G affinity chromatography |
| UniProt | P01579 |
| Localization | Cytoplasmic, membranous, extracellular (secreted) |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This IFN gamma Antibody IFNG/466 / Immune Interferon Antibody is available for research use only. |
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IFN gamma Antibody IFNG/466 / Immune Interferon Antibody recognizes interferon gamma (IFNG), a cytokine that functions as the sole member of the type II interferon family. IFNG is an important mediator of innate and adaptive immunity and is produced predominantly by activated T lymphocytes and natural killer cells. Historically known as immune interferon, IFNG coordinates cellular responses involved in host defense, inflammation, antigen presentation, and immune cell activation.
IFNG exerts its biological effects by binding the interferon gamma receptor complex composed of IFNGR1 and IFNGR2. Receptor engagement activates JAK1 and JAK2, leading primarily to STAT1 phosphorylation and transcription of interferon-responsive genes. These signaling events influence macrophage activation, antigen processing and presentation, chemokine production, and communication between innate and adaptive immune cells. The Immune Interferon also promotes expression of major histocompatibility complex molecules, supporting recognition of antigens by T cells.
Interferon gamma signaling is studied extensively in infectious disease, chronic inflammation, autoimmunity, and cancer. Within the tumor microenvironment, IFNG can enhance antigen presentation and promote immune-mediated recognition of malignant cells. Persistent IFNG signaling can also induce regulatory mechanisms that alter immune responses, illustrating the context-dependent functions of this cytokine. These diverse activities make IFNG an important target for research into cytokine signaling, tumor immunology, inflammatory pathways, and cell-mediated immunity.
Clone IFNG/466 is a mouse monoclonal antibody generated using recombinant human protein as the immunogen and recognizes both recombinant and native human IFNG. NSJ Bioreagents offers this IFN gamma Antibody for research into interferon biology and immune regulation. An IFN gamma Antibody recognizing this Immune Interferon provides a targeted reagent for investigating IFNG expression and its role in immune and inflammatory signaling.
For an alternative recombinant monoclonal clone targeting IFNG, see our Interferon gamma Antibody rIFNG/4467 / Type II Interferon Antibody page.
Optimal dilution of the IFN gamma Antibody IFNG/466 / Immune Interferon Antibody should be determined by the researcher.
Human recombinant protein was used as the immunogen for the IFN gamma Antibody IFNG/466.
Store the IFN gamma Antibody IFNG/466 at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
IFNG antibody, IFN gamma antibody, Interferon gamma antibody, Interferon-gamma antibody, Immune interferon antibody, Type II interferon antibody
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